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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2001

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Gly40Ser Polymorphism of the Glucagon Receptor Gene Is Associated with Central Adiposity in Men

Anno di pubblicazione: 2001

Formato: Cartaceo

Autori: A. Siani, R. Iacone, O. Russo, G. Barba, P. Russo, F. P. Cappuccio, F. Galletti, P. Strazzullo

Affiliazioni autori: A. Siani, G. Barba, P. Russo. Istituto di Scienze dell'Alimentazione, CNR, Avellino. F. P. Cappuccio. Dpt. of Primary Care,SGHMS Medical School, London, UK. R. Iacone, O. Russo, F. Galletti, P. Strazzullo. Dip. Medicina Clinica e Sperimentale, Università Federico II di Napoli

Autori CNR:

  • GIANVINCENZO BARBA
  • PAOLA RUSSO
  • ALFONSO SIANI

Lingua: inglese

Abstract: OBJECTIVE: To study the association between the Gly40Ser polymorphism of the glucagon receptor gene (GCG-R) and central adiposity. RESEARCH METHODS AND PROCEDURES: Data from 985 working men (The Olivetti Heart Study) examined in 1994 were used in a cross-sectional design. A complete anthropometry was performed; body mass index and waist circumference were taken as measures of total and central adiposity, respectively. The GCG-R Gly40Ser polymorphism was characterized. Biochemical variables linked to energy metabolism were measured. RESULTS: The GCG-R Gly40Ser variant was present in 37 individuals only in heterozygous form and was significantly associated with anthropometric indices of central adiposity, accounting for age and body mass (odds ratio for waist circumference > 94 cm; 95% confidence interval: 3.14, 1.26 to 7.81), whereas no difference between the two groups was found with regard to biochemical indices of insulin resistance or plasma leptin levels. DISCUSSION: The Gly40Ser polymorphism of the GCG-R gene is associated with central adiposity independently from total body mass in men.

Lingua abstract: inglese

Pagine da: 722

Pagine a: 726

Rivista:

Obesity research North American Association for the Study of Obesity,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1071-7323

Numero volume: 9

Referee: Sì: Internazionale

Indicizzato da: PubMed [11707539]

Parole chiave:

  • genetics
  • epidemiology
  • central adiposity
  • waist circumference

Altre informazioni: Fattore d'impatto 2003: 3.409

Strutture CNR:

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