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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2003

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Celiac disease association with CD8+ T cell responses: identification of a novel gliadin-derived HLA-A2-restricted epitope.

Anno di pubblicazione: 2003

Formato: Elettronico Cartaceo

Autori: Gianfrani C, Troncone R, Mugione P, Cosentini E, De Pascale M, Faruolo C, Senger S, Terrazzano G, Southwood S, Auricchio S, Sette A.

Affiliazioni autori: Institute of Food Science and Technology, Consiglio Nazionale delle Ricerche, Avellino, Italy EPIMMUNE, San Diego, CA, USA Department of Pediatrics, University of Naples, naples, Italy

Autori CNR:

  • CLEMENTINA FARUOLO
  • CARMELA GIANFRANI

Abstract: One of the diagnostic hallmarks of the histological lesions associated with celiac disease is the extensive infiltration of the small intestinal epithelium by CD8(+) T cells of unknown Ag specificity. In this study, we report recognition of the gliadin-derived peptide (A-gliadin 123-132) by CD8(+) T lymphocytes from celiac patients. A-gliadin 123-132-specific IFN-gamma production and cytotoxic activity were detected in PBMCs derived from patients on gluten-free diet, but not from either celiac patients on gluten-containing diet or healthy controls. In contrast, A-gliadin 123-132-specific cells were isolated from small intestine biopsies of patients on either gluten-free or gluten-containing diets. Short-term T cell lines derived from the small intestinal mucosa and specific for the 123-132 epitope recognized human APC pulsed with either whole recombinant alpha-gliadin or a partial pepsin-trypsin gliadin digest. Finally, we speculate on a possible mechanism leading to processing and presentation of class I-restricted gliadin-derived epitopes in celiac disease patients.

Pagine da: 2719

Pagine a: 2726

Rivista:

The Journal of immunology Williams & Wilkins,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0022-1767

Numero volume: 170

Referee: Sė: Internazionale

Parole chiave:

  • celiachia
  • gliadina
  • linfociti citotossici

Strutture CNR:

 
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