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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2020

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Influence of oral administration mode on the efficacy of commercial bovine Lactoferrin against iron and inflammatory homeostasis disorders

Anno di pubblicazione: 2020

Formato: Elettronico

Autori: Rosa L.; Lepanto M.S.; Cutone A.; Siciliano R.A.; Paesano R.; Costi R.; Musci G.; Valenti P.

Affiliazioni autori: Department of Public Health and Infectious Diseases, University of Rome, La Sapienza, Rome, 00185, Department of Public Health and Infectious Diseases, University of Rome, La Sapienza, 00185, Rome, Italy, , Italy; Department of Biosciences and Territory, University of Molise, Pesche, 86090, Department of Biosciences and Territory, University of Molise, 86090, Pesche, Italy, , Italy; Institute of Food Sciences, National Research Council, Avellino, 83100, Institute of Food Sciences, National Research Council, 83100, Avellino, Italy, , Italy; Microbo S.R.L., Rome, 00153, Microbo S.R.L., 00153, Rome, Italy, , Italy; Department of Chemistry and Technology of Drug, Institute Pasteur-Fondazione Cenci Bolognetti, University of Rome, La Sapienza, Rome, 00185, Department of Chemistry and Technology of Drug, Institute Pasteur-Fondazione Cenci Bolognetti, University of Rome, La Sapienza, 00185, Rome, Italy, , , Italy; Department of Chemistry and Technology of Drug, Institute Pasteur-Fondazione Cenci Bolognetti, University of Rome, La Sapienza, Rome, 00185, Department of Chemistry and Technology of Drug, Institute Pasteur-Fondazione Cenci Bolognetti, University of Rome, La Sapienza, 00185, Rome, Italy, , , Italy

Autori CNR:

  • ROSA ANNA SICILIANO

Lingua: inglese

Abstract: Milk derivative bovine Lactoferrin (bLf), a multifunctional glycoprotein available in large quantities and recognized as safe, possesses high homology and identical functions with human Lactoferrin. There are numerous food supplements containing bLf which, however, can vary in its purity, integrity and, consequently, functionality. Here, we report on a clinical trial where bLf (100 mg two times/day) was orally administered before (Arm A) or during meals (Arm B) to pregnant women with hereditary thrombophilia and suffering from anemia of inflammation. A significant increase of the number of red blood cells (RBCs), hemoglobin (Hb), total serum iron (TSI) and serum ferritin (sFtn) levels, along with a significant decrease of interleukin-6 were detected after 30 days in Arm A, but not in Arm B, thus letting us to hypothesize that bLf inefficacy could be related to its degradation by digestive proteases. To verify this hypothesis, bLf was incubated in gastric juice collected before or after meals. An undigested or a digested profile was observed when bLf was incubated in gastric juice sampled before or after meals, respectively. These results can explain the beneficial effect observed when bLf is administered under fasting conditions, i.e. in the absence of active proteases.

Lingua abstract: inglese

Rivista:

BioMetals Rapid Communications,
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0966-0844

DOI: 10.1007/s10534-020-00236-2

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: Scopus [2-s2.0-85083453638]

Parole chiave:

  • Anemia of inflammation; Hereditary thrombophilia; Inflammation; Iron homeostasis; Lactoferrin; Quality control

URL: http://www.scopus.com/record/display.url?eid=2-s2.0-85083453638&origin=inward

Strutture CNR:

 
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