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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Sonoghraphic hepatic/renal ratio as indicator of hepatic steatosis: comparison with 1H magnetic resonance spectroscopy
Anno di pubblicazione: 2009
Autori: Marcello Mancini; Anna Prinster; Giovanni Annuzzi; Raffaele Liuzzi; Rosalba Giacco; Carmela Medagli; Matteo Cremone; Gennaro Clemente; Simone Maurea; Gabriele Riccardi; Angela Albarosa Rivellese; Marco Salvatore.
Affiliazioni autori: IBB- CNR Napoli; IBB - CNR Napoli; Dip. Medicina Clinica e Sperimentale Napoli; IBB - CNR Napoli; ISA - CNR Avellino;IBB - CNR Napoli; IBB - CNR Napoli; ISA - CNR Avellino; IBB - CNR Napoli; Dip. Medicina Clinica e Sperimentale Napoli; Dip. Medicina Clinica e Sperimentale Napoli; IBB - CNR Napoli.
Abstract: Abstract The aim of this study was to determine the diagnostic performance of ultrasound (US) in the quantitative assessment of steatosis by comparison with proton magnetic resonance spectroscopy ((1)H-MRS) as a reference standard. Three liver echo-intensity indices were derived: US hepatic mean gray level, hepatic-renal echo-intensity ratio (H/R), and hepatic-portal blood echo-intensity ratio. The (1)H-MRS degree of steatosis was determined as percentage fat by wet weight. Regression equations were used to estimate quantitatively hepatic fat content. The hepatic fat content by (1)H-MRS analysis ranged from 0.10% to 28.9% (median value, 4.8%). Ultrasound H/R was correlated with the degree of steatosis on (1)H-MRS (R(2)= 0.92; P < .0001), whereas no correlation with (1)H-MRS was found for hepatic mean gray level and hepatic-portal blood echo-intensity ratio. A receiver operating characteristic curve identified the H/R of 2.2 as the best cutoff point for the prediction of (1)H-MRS of at least 5%, yielding measures of sensitivity and specificity of 100% and 95%, respectively. In this pilot study, US H/R exhibits high sensitivity and specificity for detecting liver fatty changes. Our results indicate that quantitative evaluation of hepatic fat content can be performed using US H/R and could therefore be a valuable analytic tool in clinical investigation.
Lingua abstract: inglese
Pagine da: 1724
Pagine a: 1730
Pagine totali: 7
Metabolism, clinical and experimental
Numero volume: 58
Numero fascicolo: 12
Referee: Sė: Internazionale
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