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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2020

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Circulating miRNAs are associated with sleep duration in children/adolescents: results of the I.Family Study

Anno di pubblicazione: 2020

Formato: Elettronico Cartaceo

Autori: Giuseppe Iacomino1, Fabio Lauria1, Paola Russo1, Pasquale Marena1, Antonella Venezia1, Nunzia Iannaccone1, Stefaan De Henauw2, Ronja Foraita3, Regina Heidinger-Fels?4, Monica Hunsberger5, Yiannis Kourides6, Luis A Moreno7, Barbara Thumann3, Toomas Veidebaum8, Alfonso Siani1

Affiliazioni autori: 1) Institute of Food Sciences, National Research Council, ISA-CNR, via Roma 64, 83100, Avellino-Italy; 2) University of Ghent, C. Heymanslaan 10, 4K3 9000, Gent-Belgium; 3) Leibniz Institute for Prevention Research and Epidemiology, BIPS, Achterstraße 30, 28359, Bremen-Germany; 4) Medical School, University of Pécs, Szigeti út 12, 7624, Pécs -Hungary; 5) Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 3, 413 90, Göteborg-Sweden; 6) Research and Education Institute of Child Health, 138, Limassol ave, #205 2015, Strovolos-Cyprus; 7) University of Zaragoza, Spain; Domingo Miral, s/n, 50009, Zaragoza-Spain; 8) National Institute for Health Development, Hiiu 42, 11619, Tallinn-Estonia

Autori CNR:


Lingua: inglese

Abstract: It is commonly recognized that sleep is essential for children's health, and that insufficient sleep duration is associated with negative health outcomes. In humans, sleep duration and quality are influenced by genetic, environmental and social factors. Epigenetic mechanisms, likewise, regulate circadian rhythms and sleep patterns. In the present study, we aimed to identify circulating microRNAs associated with sleep duration in a subsample of normal-weight European children/adolescents (n=111) participating in the I.Family Study. Study subjects were divided into two groups based upon the self-reported sleep duration, according to the recommended amount of sleep for pediatric populations. Sleep needs for children <13 years were at least 9 hours per day, and for children >13 were at least 8 hours per day. There were group differences (short sleepers versus normal sleepers) in circulating levels of miR-26b-3p [mean (I.C.)] = 2.0 (1.3 - 2.7) versus 2.3 (1.9 - 2.7), p-value = 0.05 and miR-485-5p [mean (I.C.)] = 0.6 (0.3 - 0.9) versus 0.9 (0.7 - 1.0), p-value < 0.001 adjusting for country of origin, age, sex, pubertal status, screen time, and highest educational level of parents. Our findings show for the first time that the sleep duration reflects the profile of specific circulating microRNAs in school-aged children and adolescents. It is conceivable that epigenetic modifications, mainly related to circadian rhythm control, may be modulated or interfere with sleep duration.

Lingua abstract: inglese


Experimental physiology Cambridge University Press.
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0958-0670

DOI: 10.1113/EP088015

Referee: Sě: Internazionale

Stato della pubblicazione: Published version

Parole chiave:


URL: https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/EP088015

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