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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Circulating miRNAs are associated with sleep duration in children/adolescents: results of the I.Family Study
Anno di pubblicazione: 2020
Formato: Elettronico Cartaceo
Autori: Giuseppe Iacomino1, Fabio Lauria1, Paola Russo1, Pasquale Marena1, Antonella Venezia1, Nunzia Iannaccone1, Stefaan De Henauw2, Ronja Foraita3, Regina Heidinger-Fels?4, Monica Hunsberger5, Yiannis Kourides6, Luis A Moreno7, Barbara Thumann3, Toomas Veidebaum8, Alfonso Siani1
Affiliazioni autori: 1) Institute of Food Sciences, National Research Council, ISA-CNR, via Roma 64, 83100, Avellino-Italy; 2) University of Ghent, C. Heymanslaan 10, 4K3 9000, Gent-Belgium; 3) Leibniz Institute for Prevention Research and Epidemiology, BIPS, Achterstraße 30, 28359, Bremen-Germany; 4) Medical School, University of Pécs, Szigeti út 12, 7624, Pécs -Hungary; 5) Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 3, 413 90, Göteborg-Sweden; 6) Research and Education Institute of Child Health, 138, Limassol ave, #205 2015, Strovolos-Cyprus; 7) University of Zaragoza, Spain; Domingo Miral, s/n, 50009, Zaragoza-Spain; 8) National Institute for Health Development, Hiiu 42, 11619, Tallinn-Estonia
Abstract: It is commonly recognized that sleep is essential for children's health, and that insufficient sleep duration is associated with negative health outcomes. In humans, sleep duration and quality are influenced by genetic, environmental and social factors. Epigenetic mechanisms, likewise, regulate circadian rhythms and sleep patterns. In the present study, we aimed to identify circulating microRNAs associated with sleep duration in a subsample of normal-weight European children/adolescents (n=111) participating in the I.Family Study. Study subjects were divided into two groups based upon the self-reported sleep duration, according to the recommended amount of sleep for pediatric populations. Sleep needs for children <13 years were at least 9 hours per day, and for children >13 were at least 8 hours per day. There were group differences (short sleepers versus normal sleepers) in circulating levels of miR-26b-3p [mean (I.C.)] = 2.0 (1.3 - 2.7) versus 2.3 (1.9 - 2.7), p-value = 0.05 and miR-485-5p [mean (I.C.)] = 0.6 (0.3 - 0.9) versus 0.9 (0.7 - 1.0), p-value < 0.001 adjusting for country of origin, age, sex, pubertal status, screen time, and highest educational level of parents. Our findings show for the first time that the sleep duration reflects the profile of specific circulating microRNAs in school-aged children and adolescents. It is conceivable that epigenetic modifications, mainly related to circadian rhythm control, may be modulated or interfere with sleep duration.
Lingua abstract: inglese
Cambridge University Press.
Referee: Sě: Internazionale
Stato della pubblicazione: Published version
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