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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2016

Contributo in rivista

Tipo: Rassegna della letteratura scientifica in rivista (Literature review)

Titolo: Nrf2 as molecular target for polyphenols: A novel therapeutic strategy in diabetic retinopathy

Anno di pubblicazione: 2016

Formato: Elettronico Cartaceo

Autori: Nabavi, Seyed Fazel; Barber, Alistair J.; Spagnuolo, Carmela; Russo, Gian Luigi; Daglia, Maria; Nabavi, Seyed Mohammad; Sobarzo-Sanchez, Eduardo

Affiliazioni autori: Baqiyatallah Univ Med Sci; Penn State Hershey Coll Med; CNR; Univ Pavia; Univ Santiago de Compostela

Autori CNR:

  • GIAN LUIGI RUSSO
  • CARMELA SPAGNUOLO

Lingua: inglese

Abstract: Diabetic retinopathy is a microvascular complication of diabetes that is considered one of the leading causes of blindness among adults. More than 4.4 million people suffer from this disorder throughout the world. Growing evidence suggests that oxidative stress plays a crucial role in the pathophysiology of diabetic retinopathy. Nuclear factor erythroid 2-related factor 2 (Nrf2), a redox sensitive transcription factor, plays an essential protective role in regulating the physiological response to oxidative and electrophilic stress via regulation of multiple genes encoding antioxidant proteins and phase II detoxifying enzymes. Many studies suggest that dozens of natural compounds, including polyphenols, can supress oxidative stress and inflammation through targeting Nrf2 and consequently activating the antioxidant response element-related cytoprotective genes. Therefore, Nrf2 may provide a new therapeutic target for treatment of diabetic retinopathy. In the present article, we will focus on the role of Nrf2 in diabetic retinopathy and the ability of polyphenols to target Nrf2 as a therapeutic strategy.

Lingua abstract: inglese

Lingua altro abstract: inglese

Pagine da: 293

Pagine a: 312

Pagine totali: 20

Rivista:

Critical reviews in clinical laboratory sciences CRC Press,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1040-8363

Numero volume: 53

Numero fascicolo: 5

DOI: 10.3109/10408363.2015.1129530

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: ISI Web of Science (WOS) [000377043600001]

Parole chiave:

  • Diabetic retinopathy
  • polyphenols
  • antioxidant response element
  • Nrf2

URL: https://www.tandfonline.com/doi/abs/10.3109/10408363.2015.1129530

Strutture CNR:

 
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