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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2016

Contributo in rivista

Tipo: Articolo in rivista

Titolo: A Phenolic Extract Obtained from Methyl Jasmonate-Treated Strawberries Enhances Apoptosis in a Human Cervical Cancer Cell Line

Anno di pubblicazione: 2016

Formato: Elettronico Cartaceo

Autori: Spagnuolo, Carmela; Flores, Gema; Russo, Gian Luigi; Luisa Ruiz del Castillo, Maria

Affiliazioni autori: CNR; CSIC

Autori CNR:

  • GIAN LUIGI RUSSO
  • CARMELA SPAGNUOLO

Lingua: inglese

Abstract: In the present study, we evaluated the effect of methyl jasmonate (MeJA) treatment on strawberry phenolic composition. Strawberry extracts contain a mixture of phenolic compounds possessing several biological properties. We demonstrated that these extracts were more effective in inducing apoptosis in HeLa cells compared to phenolic preparations derived from untreated strawberries. Treatment of strawberries with 0.5% MeJA resulted in increased polyphenols content (from 7.4 to 8.6mM quercetin equivalents) and antioxidant properties (from 3.9 to 4.6mM quercetin equivalents). The identification and quantification of phenolic compounds by liquid chromatography-mass spectrometry in the strawberry extracts showed that cyanidin glucoside, pelargonidin glucoside, and ellagic glucoside acid were significantly higher in strawberries treated with MeJA. Phenolic extracts from MeJA-treated strawberries significantly decreased the cell viability in HeLa cells, compared to extracts derived from untreated fruits. We hypothesized that the enhanced apoptotic activity of MeJA-treated strawberries was due to a synergistic or additive effect of different phenolic compounds present in the extract, rather than the activity of a single molecule.

Lingua abstract: inglese

Pagine da: 1140

Pagine a: 1150

Pagine totali: 11

Rivista:

Nutrition and cancer Routledge, Taylor & Francis Group
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0163-5581

Numero volume: 68

Numero fascicolo: 7

DOI: 10.1080/01635581.2016.1208831

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: ISI Web of Science (WOS) [000384224100009]

Parole chiave:

  • Methyl Jasmonate
  • apoptosis
  • strawberries

URL: https://www.tandfonline.com/doi/abs/10.1080/01635581.2016.1208831

Strutture CNR:

 
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