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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2017

Contributo in rivista

Tipo: Articolo in rivista

Titolo: A Carotenoid Extract from a Southern Italian Cultivar of Pumpkin Triggers Nonprotective Autophagy in Malignant Cells

Anno di pubblicazione: 2017

Formato: Elettronico

Autori: Russo, Maria; Moccia, Stefania; Bilotto, Stefania; Spagnuolo, Carmela; Durante, Miriana; Lenucci, Marcello Salvatore; Mita, Giovanni; Volpe, Maria Grazia; Aquino, Rita Patrizia; Russo, Gian Luigi

Affiliazioni autori: CNR; CNR; Univ Salento; Univ Salerno

Autori CNR:

  • STEFANIA BILOTTO
  • MIRIANA DURANTE
  • GIOVANNI MITA
  • GIAN LUIGI RUSSO
  • MARIA RUSSO
  • CARMELA SPAGNUOLO
  • MARIA GRAZIA VOLPE

Lingua: inglese

Abstract: Carotenoids, including beta-carotene, lycopene, and derivatives, such as retinoic acid, have been studied for their significant antiproliferative and differentiating activity on cancer cells in experimental models and in clinics. We are presenting here data on the mechanism of action of a carotenoid-enriched extract obtained from the pumpkin Cucurbita moschata, variety "long of Naples," on two malignant human cell lines, Caco-2 and SAOs, derived from a colon adenocarcinoma and an osteosarcoma, respectively. The carotenoid extract has been obtained from pumpkin pulp and seeds by supercritical CO2 extraction and employed to prepare oil-in-water nanoemulsions. The nanoemulsions, applied at a final carotenoid concentration of 200-400 mu g/ml, were not cytotoxic, but induced a delay in cell growth of about 40% in both SAOs and Caco-2 cell lines. This effect was associated with the activation of a "nonprotective" form of autophagy and, in SAOs cells, to the induction of cell differentiation via a mechanism that involved AMPK activation. Our data suggest the presence of a pool of bioactive compounds in the carotenoid-enriched extract, acting additively, or synergistically, to delay cell growth in cancer cells.

Lingua abstract: inglese

Pagine da: 1

Pagine a: 15

Pagine totali: 15

Rivista:

Oxidative medicine and cellular longevity Landes Bioscience
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1942-0994

DOI: 10.1155/2017/7468538

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: ISI Web of Science (WOS) [000419055000001]

Parole chiave:

  • carotenoids
  • autopahgy

URL: https://www.hindawi.com/journals/omcl/2017/7468538/abs/

Strutture CNR:

 
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