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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2017

Contributo in rivista

Tipo: Abstract in rivista

Titolo: Ins and Outs of Flavonoids in Cancer Prevention vs. Cancer Therapy: A Lesson from Quercetin in Leukemia

Anno di pubblicazione: 2017

Formato: Elettronico

Autori: Gian Luigi Russo Russo , Maria usso, Carmela Spagnuolo and Stefania Moccia

Affiliazioni autori: Institute of Food Sciences, National Research Council, Avellino 83100, Italy

Autori CNR:

  • STEFANIA MOCCIA
  • GIAN LUIGI RUSSO
  • MARIA RUSSO
  • CARMELA SPAGNUOLO

Lingua: inglese

Abstract: We recently critically reviewed clinical and pre-clinical studies on the concept that polyphenols, being antioxidant compounds, can fight cancer. We suggest that a clear distinction must be done between the use of polyphenols, such as flavonoids, in cancer treatment versus cancer prevention, starting from adequate and specifically selected cellular models. As an example, we will present data on the potential application of quercetin against chronic lymphocytic leukemia (CLL). Previous studies from our group indicated that quercetin synergistically sensitizes to apoptosis several leukemic cell lines and B-cells isolated from CLL patients, when associated with other pro-apoptotic agents. Using HG3 cells, derived from primary B-cells immortalized with Epstein-Barr virus, we demonstrated that the association between ABT-737, a BH3-mimetics, and quercetin synergistically induces apoptosis through the inhibition of PI3K/Akt signaling pathway. More importantly, we identified the protein kinase CK2 as a new, direct and primary target of quercetin, since CK2 activity was inhibited by the flavonoid within one minute from the treatment. Considering the rapid uptake of quercetin and its low toxicity against normal peripheral blood cells, we recommend the design of clinical studies aimed to demonstrate the potential use of the molecule in the adjuvant chemotherapy against CLL.

Pagine da: 977

Pagine a: 977

Pagine totali: 1

Rivista:

Proceedings MDPI
Paese di pubblicazione: Svizzera
Lingua: inglese
ISSN: 2504-3900

Numero volume: 1

Numero fascicolo: 10

DOI: 10.3390/proceedings1100977

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Parole chiave:

  • quercetin; chemoprevention; chronic lymphocytic leukemia; antioxidants

URL: https://www.mdpi.com/2504-3900/1/10/977

Altre informazioni: Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8-11 November 2017.

Strutture CNR:

 
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