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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2018

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment

Anno di pubblicazione: 2018

Autori: Russo, Maria; Spagnuolo, Carmela; Russo, Gian Luigi; Skalicka-Wozniak, Krystyna; Daglia, Maria; Sobarzo-Sanchez, Eduardo; Nabavi, Seyed Fazel; Nabavi, Seyed Mohammad

Affiliazioni autori: CNR; Med Univ Lublin; Univ Pavia; Univ Santiago de Compostela; Baqiyatallah Univ Med Sci

Autori CNR:

  • GIAN LUIGI RUSSO
  • MARIA RUSSO
  • CARMELA SPAGNUOLO

Lingua: inglese

Abstract: In the past decades, extensive studies have reported the potential chemopreventive activity of sulforaphane, an isothiocyanate derived from glucoraphanin, occurring in large amounts in Brassica genus plants. Sulforaphane was found to be active against several forms of cancer. A growing body of data shows that sulforaphane acts against cancer at different levels, from development to progression, through pleiotropic effects. In this review, we discuss the available experimental and clinical data on the potential therapeutic role of sulforaphane against cancer. Its effects range from the protection of cells from DNA damage to the modulation of the cell cycle via pro-apoptotic, anti-angiogenesis and anti-metastasis activities. At molecular level, sulforaphane modulates cellular homeostasis via the activation of the transcription factor Nrf2. Although data from clinical studies are limited, sulforaphane remains a good candidate in the adjuvant therapy based on natural molecules against several types of cancer.

Lingua abstract: inglese

Pagine da: 1391

Pagine a: 1405

Pagine totali: 15

Rivista:

Critical reviews in food science and nutrition CRC Press,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1040-8398

Numero volume: 58

Numero fascicolo: 8

DOI: 10.1080/10408398.2016.1259983

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: ISI Web of Science (WOS) [000431691700011]

Parole chiave:

  • Antioxidant
  • Nrf2
  • sulforaphane
  • cancer

URL: https://www.tandfonline.com/doi/abs/10.1080/10408398.2016.1259983

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