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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2018

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Anti-inflammatory effects of flavonoids in neurodegenerative disorders

Anno di pubblicazione: 2018

Autori: Spagnuolo, Carmela; Moccia, Stefania; Russo, Gian Luigi

Affiliazioni autori: CNR

Autori CNR:


Lingua: inglese

Abstract: Neuroinflammation is one of the main mechanisms involved in the progression of several neurodegenerative diseases, such as Parkinson, Alzheimer, multiple sclerosis, amyotrophic lateral sclerosis and others. The activation of microglia is the main feature of neuroinflammation, promoting the release of pro-inflammatory cytokines and resulting in the progressive neuronal cell death. Natural compounds, such as flavonoids, possess neuroprotective potential probably related to their ability to modulate the inflammatory responses involved in neurodegenerative diseases. In fact, pure flavonoids (e.g., quercetin, genistein, hesperetin, epigallocatechin-3-gallate) or enriched-extracts, can reduce the expression of pro inflammatory cytokines (IL-6, TNF-alpha, IL-1 and COX-2), down-regulate inflammatory markers and prevent neural damage. This anti-inflammatory activity is primarily related to the regulation of microglial cells, mediated by their effects on MAPK5 and NF-kappa B signalling pathways, as demonstrated by in vivo and in vitro data. The present work reviews the role of inflammation in neurodegenerative diseases, highlighting the potential therapeutic effects of flavonoids as a promising approach to develop innovative neuroprotective strategy. (C) 2017 Elsevier Masson SAS. All rights reserved.

Lingua abstract: inglese

Pagine da: 105

Pagine a: 115

Pagine totali: 11


European journal of medicinal chemistry Elsevier
Paese di pubblicazione: Francia
Lingua: multilingue
ISSN: 0223-5234

Numero volume: 153

DOI: 10.1016/j.ejmech.2017.09.001

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: ISI Web of Science (WOS) [000436223000009]

Parole chiave:

  • Flavonoids
  • Neuroinflammation
  • Neurodegeneration

URL: https://www.sciencedirect.com/science/article/pii/S0223523417306839

Strutture CNR:

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