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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2016

Contributo in rivista

Tipo: Rassegna della letteratura scientifica in rivista (Literature review)

Titolo: Systematic review and meta-analysis of randomised controlled trials on the effects of potassium supplements on serum potassium and creatinine

Anno di pubblicazione: 2016

Autori: Cappuccio, Francesco P.; Buchanan, Laura A.; Ji, Chen; Siani, Alfonso; Miller, Michelle A.

Affiliazioni autori: Division of Health Sciences (Mental Health & Wellbeing), University of Warwick, WHO Collaborating Centre for Nutrition, Warwick Medical School, Coventry, UK; Institute of Food Sciences, National Research Council, Avellino, Italy.

Autori CNR:


Lingua: inglese

Abstract: OBJECTIVES: High potassium intake could prevent stroke, but supplementation is considered hazardous. We assessed the effect of oral potassium supplementation on serum or plasma potassium levels and renal function. SETTING: We updated a systematic review of the effects of potassium supplementation in randomised clinical trials carried out worldwide, published in 2013, extending it to July 2015. We followed the PRISMA guidelines. PARTICIPANTS: Any individual taking part in a potassium supplementation randomised clinical trial. Studies included met the following criteria: randomised clinical trials, potassium supplement given and circulating potassium levels reported. INTERVENTION: Oral potassium supplementation. PRIMARY OUTCOME MEASURES: Serum or plasma potassium and serum or plasma creatinine. RESULTS: A total of 20 trials (21 independent groups) were included (1216 participants from 12 different countries). All but 2 were controlled (placebo n=16, control n=2). Of these trials, 15 were crossover, 4 had a parallel group and 1 was sequential. The duration of supplementation varied from 2 to 24 weeks and the amount of potassium given from 22 to 140 mmol/day. In the pooled analysis, potassium supplementation caused a small but significant increase in circulating potassium levels (weighted mean difference (WMD) 0.14 mmol/L, 95% CI 0.09 to 0.19, p<1×10(-5)), not associated with dose or duration of treatment. The average increase in urinary potassium excretion was 45.75 mmol/24 hours, 95% CI 38.81 to 53.69, p<1×10(-5). Potassium supplementation did not cause any change in circulating creatinine levels (WMD 0.30 µmol/L, 95% CI -1.19 to 1.78, p=0.70). CONCLUSIONS: In short-term studies of relatively healthy persons, a moderate oral potassium supplement resulted in a small increase in circulating potassium levels and no change in renal function.

Lingua abstract: inglese

Pagine totali: 10


BMJ open BMJ Publishing
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 2044-6055

Numero volume: 6

Numero fascicolo: 8

DOI: 10.1136/bmjopen-2016-011716

Referee: Sì: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: ISI Web of Science (WOS) [000382336700024]

Parole chiave:

  • meta-analysis
  • potassium supplements
  • randomized clinical trials
  • systematic review
  • serum potassium

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013341/

Strutture CNR:


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