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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2016

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Theoretical insight into the heat shock response (HSR) regulation in Lactobacillus casei and L. rhamnosus

Anno di pubblicazione: 2016

Formato: Elettronico

Autori: Rossi, Franca; Zotta, Teresa; Iacumin, Lucilla; Reale, Anna

Affiliazioni autori: Univ Verona; CNR; Univ Udine

Autori CNR:

  • ANNA REALE
  • TERESA ZOTTA

Lingua: inglese

Abstract: The understanding of the heat shock response (HSR) in lactobacilli from a regulatory point of view is still limited, though an increased knowledge on the regulation of this central stress response can lead to improvements in the exploitation of these health promoting microorganisms. Therefore the aim of this in silica study, that is the first to be carried out for members of the Lactobacillus genus, was predicting how HSR influences cell functions in the food associated and probiotic species Lactobacillus casei and Lactobacillus rhamnosus.

Lingua abstract: inglese

Altro abstract: To this purpose, thirteen whole genomes of these bacteria were analyzed to identify which genes involved in HSR are present. It was found that all the genomes share 25 HSR related genes, including those encoding protein repair systems, HSR repressors, HrcA and CtsR, and the positive regulators of HSR, alternative a factors sigma(32) and sigma(24). Two genes encoding a sigma(70)/sigma(24) factor and a Lon protease, respectively, were found only in some genomes.

Pagine da: 21

Pagine a: 37

Pagine totali: 17

Rivista:

Journal of theoretical biology Academic Press,
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0022-5193

Numero volume: 402

DOI: 10.1016/j.jtbi.2016.04.029

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: ISI Web of Science (WOS) [000377623700004]

Parole chiave:

  • HSR regulation
  • HrcA
  • CtsR
  • sigma(32)
  • sigma(24)
  • Promoter consensus
  • Regulon composition
  • Stress tolerance

Strutture CNR:

 
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