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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2018

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Proteomics pattern associated with gingival oral squamous cell carcinoma and epulis: A case analysis

Anno di pubblicazione: 2018

Autori: Papa, Francesco; Siciliano, Rosa Anna; Inchingolo, Francesco; Mazzeo, Maria Fiorella; Scacco, Salvatore; Lippolis, Rosa

Affiliazioni autori: Univ Aldo Moro; Natl Res Council CNR; Univ Aldo Moro; Italian Natl Res Council CNR

Autori CNR:

  • ROSA LIPPOLIS
  • MARIA FIORELLA MAZZEO
  • ROSA ANNA SICILIANO

Lingua: inglese

Abstract: Objectives: Oral squamous cell carcinoma (OSCC) is the most common epithelial malignant neoplasm affecting the oral cavity. OSCC can mimic oral lesions of inflammatory origin with benign features, often leading to delay in diagnosis and treatment. Early detection is important to greatly increase the chances of a successful treatment. The present study reports a proteomic analysis of a gingival oral squamous cell carcinoma (G-OSCC) and an epulis.

Lingua abstract: inglese

Altro abstract: Materials and methods: Normal mucosae tissue, G-OSCC tissue, and epulis tissue as a comparative sample of benign nature were collected and immediately frozen in liquid nitrogen. Tissue-extracted proteins were separated by two-dimensional gel electrophoresis and subjected to image analysis. Proteins that showed a significant difference in the expression level in the G-OSCC tissue were identified by the nano-ESI-HPLC-MS/MS experiment and database searchi.

Pagine da: 41

Pagine a: 47

Pagine totali: 7

Rivista:

Oral science international Japanese Stomatological Society
Paese di pubblicazione: Giappone
Lingua: inglese
ISSN: 1348-8643

Numero volume: 15

Numero fascicolo: 2

DOI: 10.1016/S1348-8643(17)30044-7

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: ISI Web of Science (WOS) [000437660700001]

Parole chiave:

  • Biomarkers
  • Proteomic analysis
  • Oral squamous cell carcinoma

Strutture CNR:

 
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