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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2017

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Phytochemical composition, anti-biofilm and anti-quorum sensing potential of fruit, stem and leaves of Salvadora persica L. methanolic extracts

Anno di pubblicazione: 2017

Autori: Noumi E.; Snoussi M.; Merghni A.; Nazzaro F.; Quindos G.; Akdamar G.; Mastouri M.; Al-Sieni A.; Ceylan O.

Affiliazioni autori: Laboratory of Transmissible Diseases and Biologically Active Substances, Faculty of Pharmacy, University of Monastir, , Tunisia; Laboratory of Treatment and Valorization of Water Discharges (CERTE, Borj Cedria), Soliman, 8020, , Tunisia; Ula Ali Kocman Vocational School, Mugla Sitki Kocman University, Mugla, , Turkey; Department of Biochemistry, Faculty of Science, King Abdul Aziz University, Jeddah, , Saudi Arabia; Institute of Food Science National Research Council (ISA-CNR), Via Roma, Avellino, 64 83100, , , Italy; Institute of Food Science National Research Council (ISA-CNR), Via Roma, Avellino, 64 83100, , , Italy; Department of Microbiology and Parasitology, Faculty of Medicine and Odontology, Bilbao, , Spain

Autori CNR:

  • FLORINDA FRATIANNI
  • FILOMENA NAZZARO

Lingua: inglese

Abstract: Emergence of antibiotic resistance among pathogenic bacteria encourages us to search for new molecules as an alternative treatment. The aim of this study was to evaluate the antiquorum sensing (anti-QS) and antibiofilm potential of Salvadora persica L. methanolic extracts to prevent the infections due to Staphylococcus as an alternate to antibiotics. The methanolic extracts of S. persica L. fruit, leaves and stems was assessed for their activity in inhibiting QS-depedent phenomenon such as violacein pigment production in Chromobacterium violaceum, swarming motility of Pseudomonas aeruginosa PAO1 and biofilm formation in oral Staphylococcus strains on polymethylmetacrylate (PMMA). Methanolic fruit extract of S. persica L. showed a high degree of anti-biofilm formation on PMMA and on violacein inhibition with a percentage of reduction equal to 90% when MIC value (20 mg/ml) was used. 100 ?g/ml of S. persica L. leaves exhibited inhibition in swarming motility of PAO1 at 29.17%. Because the methanolic extracts of S. persica L. demonstrated anti-QS and antibiofilm activity at very low concentrations, it could be further exploited for novel molecules to treat oral Staphylococcus infections.

Lingua abstract: inglese

Pagine da: 169

Pagine a: 176

Rivista:

Microbial pathogenesis Academic Press.
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0882-4010

Numero volume: 109

DOI: 10.1016/j.micpath.2017.05.036

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: Scopus [2-s2.0-85020317495]

Parole chiave:

  • antimicrobial
  • quorum sensing
  • vegetal extracts

URL: http://www.scopus.com/record/display.url?eid=2-s2.0-85020317495&origin=inward

Strutture CNR:

 
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