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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2018

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Bioavailability and pharmacokinetic profile of grape pomace phenolic compounds in humans

Anno di pubblicazione: 2018

Autori: Castello, Fabio; Costabile, Giuseppina; Bresciani, Letizia; Tassotti, Michele; Naviglio, Daniele; Luongo, Delia; Ciciola, Paola; Vitale, Marilena; Vetrani, Claudia; Galaverna, Gianni; Brighenti, Furio; Giacco, Rosalba; Del Rio, Daniele; Mena, Pedro

Affiliazioni autori: Univ Parma; Federico II Univ Naples; Federico II Univ Naples; CNR Inst Biostruct & Bioimaging; CNR; Univ Parma; Univ Parma

Autori CNR:

  • ROSALBA GIACCO

Lingua: inglese

Abstract: Grape pomace, the major byproduct of the wine and juice industry, is a relevant source of bioactive phenolic compounds. However, polyphenol bioavailability in humans is not well understood, and the inter-individual variability in the production of phenolic metabolites has not been comprehensively assessed to date. The pharmacokinetic and excretive profiles of phenolic metabolites after the acute administration of a drink made from red grape pomace was here investigated in ten volunteers. A total of 35 and 28 phenolic metabolites were quantified in urine and plasma, respectively. The main circulating metabolites included phenyl-gamma-valerolactones, hydroxybenzoic acids, simple phenols, hydroxyphenylpropionic acids, hydroxycinnamates, and (epi)catechin phase II conjugates. A high inter-individual variability was shown both in urine and plasma samples, and different patterns of circulating metabolites were unravelled by applying unsupervised multivariate analysis. Besides the huge variability in the production of microbial metabolites of colonic origin, an important variability was observed due to phase II conjugates. These results are of interest to further understand the potential health benefits of phenolic metabolites on individual basis.

Lingua abstract: inglese

Pagine da: 1

Pagine a: 9

Pagine totali: 9

Rivista:

Archives of biochemistry and biophysics Elsevier Inc.
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0003-9861

Numero volume: 646

DOI: 10.1016/j.abb.2018.03.021

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: ISI Web of Science (WOS) [000431838200001]

Parole chiave:

  • Grape pomace
  • Phenolic metabolite
  • Bioavailability
  • Metabolism
  • Colonic catabolite
  • Phenyl-gamma-valerolactone

Strutture CNR:

 
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