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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2018

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Brain Nrf2 pathway, autophagy, and synaptic function proteins are modulated by a short-term fructose feeding in young and adult rats

Anno di pubblicazione: 2018

Formato: Elettronico

Autori: Maria Stefania Spagnuolo, Paolo Bergamo, Raffaella Crescenzo, Lucia Iannotta, Lucia Treppiccione, Susanna Iossa, Luisa Cigliano

Affiliazioni autori: Department of Bio-Agrofood Science, Institute for the Animal Production System in Mediterranean Environment, National Research Council (CNR-ISPAAM), Naples, Italy, Department of Bio-Agrofood Science, Institute of Food Sciences, National Research Council (CNR-ISA), Avellino, Italy, 3Department of Biology, University of Naples Federico II, Naples, Italy

Autori CNR:


Lingua: inglese

Abstract: Objectives: A strong rise of the fructose content in the human diet occurred in the last decade, as corn syrup is widely used as a sweetener for beverages and processed food. Since young people make a widespread consumption of added sugars, we evaluated the effects of a two weeks fructose-rich diet on brain redox homeostasis, autophagy and synaptic plasticity in the cortex of young and adults rats, in order to highlight the early risks to which brain is exposed. Methods and Results: Short-term fructose feeding was associated with an imbalance of redox homeostasis, as lower amount of Nuclear factor (erythroid derived 2)-like 2, lower activity of Glucose 6-phosphatedehydrogenase and Glutathione reductase, together with lower Glutathione/Oxidized Glutathione ratio, were found in fructose-fed young and adult rats. Fructose-rich diet was also associated with the activation of autophagy, as higher levels of Beclin, LC3 II and P62 were detected in cortex of fructose-fed rats. Adiet associated decrease of synaptophysin, synapsin I, and synaptotagmin I, was found in fructose-fed young and adult rats. Interestingly, BDNF amount was significantly lower only in fructose-fed adult rats,while the level of its receptor TrkB decreased in both groups of treated rats. A further marker of brain functioning, Acetylcholinesterase activity, was found increased only in fructose-fed young animals. Conclusion: Overall, our findings suggest that young rats may severely suffer from the deleterious influence of fructose on brain health as the adults and provide experimental data suggesting the need of targetednutritional strategies to reduce its amount in foods.

Lingua abstract: inglese

Pagine da: 309

Pagine a: 320

Pagine totali: 12


Nutritional neuroscience Harwood Academic Publishers
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 1028-415X

Numero volume: 23

Numero fascicolo: 4

DOI: 10.1080/1028415X.2018.1501532

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Parole chiave:

  • Fructose diet
  • Rat cortex
  • Synaptic proteins
  • Brain-derived neurotrophic factor
  • Redox homeostasis
  • Nrf2
  • Autophagy

URL: https://doi.org/10.1080/1028415X.2018.1501532

Data di accettazione: 24/07/2018

Strutture CNR:

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