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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Conjugated linoleic acid prevents age-dependent neurodegeneration in a mouse model of neuropsychiatric lupus via the activation of an adaptive response.
Anno di pubblicazione: 2018
Formato: Elettronico Cartaceo
Autori: Monaco A, Ferrandino I, Boscaino F, Cocca E, Cigliano L, Maurano F, Luongo D, Spagnuolo MS, Rossi M, Bergamo P.
Affiliazioni autori: University - Federico II - of Naples, Italy; Institute of Food Sciences, National Research Council (CNR-ISA), Italy. Institute of Biosciences and Bioresources, National Research Council (IBBR-CNR), Italy; Istituto per il Sistema Produzione Animale in Ambiente Mediterraneo, National Research Council (ISPAAM-CNR)
Abstract: Oxidative stress is a key mediator of autoimmune/neurodegenerative disorders. The antioxidant/anti-inflammatory effect of a synthetic conjugated linoleic acid (CLA) mixture in MRL/MpJ-Faslpr mice (MRL/lpr), an animal model of neuropsychiatric lupus, was previously associated with the improvement of Nuclear factor-E2-related factor 2 (Nrf2) defences in the spleen and liver. However, little is known about the neuroprotective ability of CLA mixture. This study investigates the age-dependent progression of oxidative stress and the hyperactivation of redox-sensitive compensatory pathways (macroautophagy, Nrf2) in old/diseased MRL/lpr mice brains, and examines the effect produced by dietary CLA supplementation. Disrupted redox homeostasis was evidenced in the blood, liver and brain of 21- to 22-week old MRL/lpr mice (Old) compared to young animals (Y; 8- to 10-week old). This alteration was associated with significant hyperactivation of compensatory mechanisms (macroautophagy, Nrf2 and astrocyte activation) in the brains of Old mice. Five-week daily supplementation with CLA (650 mg/kg-1 body weight) of 16-week old mice (CLA+Old) diminished all the pathological hallmarks at a level comparable to Y mice or healthy controls (BALB/c). Such data demonstrated that MRL/lpr mice can serve as a valuable model for the evaluation of the effectiveness of neuroprotective drugs. Notably, the preventive effect provided by CLA supplementation against age-associated neuronal damage and hyperactivation of compensatory mechanisms suggests that the activation of an adaptive response is, at least in part, accountable for its neuroprotective ability.
Lingua abstract: inglese
Pagine da: 48
Pagine a: 57
Pagine totali: 10
Journal of lipid research
American Society for Biochemistry and Molecular Biology
Numero volume: 59
Numero fascicolo: 1
Referee: Sė: Internazionale
Stato della pubblicazione: Published version
Data di accettazione: 15/12/2017
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