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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2018

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Conjugated linoleic acid prevents age-dependent neurodegeneration in a mouse model of neuropsychiatric lupus via the activation of an adaptive response.

Anno di pubblicazione: 2018

Formato: Elettronico Cartaceo

Autori: Monaco A, Ferrandino I, Boscaino F, Cocca E, Cigliano L, Maurano F, Luongo D, Spagnuolo MS, Rossi M, Bergamo P.

Affiliazioni autori: University - Federico II - of Naples, Italy; Institute of Food Sciences, National Research Council (CNR-ISA), Italy. Institute of Biosciences and Bioresources, National Research Council (IBBR-CNR), Italy; Istituto per il Sistema Produzione Animale in Ambiente Mediterraneo, National Research Council (ISPAAM-CNR)

Autori CNR:

  • PAOLO BERGAMO
  • FLORIANA BOSCAINO
  • ENNIO COCCA
  • DIOMIRA LUONGO
  • FRANCESCO MAURANO
  • MAURO ROSSI
  • MARIA STEFANIA SPAGNUOLO

Lingua: inglese

Abstract: Oxidative stress is a key mediator of autoimmune/neurodegenerative disorders. The antioxidant/anti-inflammatory effect of a synthetic conjugated linoleic acid (CLA) mixture in MRL/MpJ-Faslpr mice (MRL/lpr), an animal model of neuropsychiatric lupus, was previously associated with the improvement of Nuclear factor-E2-related factor 2 (Nrf2) defences in the spleen and liver. However, little is known about the neuroprotective ability of CLA mixture. This study investigates the age-dependent progression of oxidative stress and the hyperactivation of redox-sensitive compensatory pathways (macroautophagy, Nrf2) in old/diseased MRL/lpr mice brains, and examines the effect produced by dietary CLA supplementation. Disrupted redox homeostasis was evidenced in the blood, liver and brain of 21- to 22-week old MRL/lpr mice (Old) compared to young animals (Y; 8- to 10-week old). This alteration was associated with significant hyperactivation of compensatory mechanisms (macroautophagy, Nrf2 and astrocyte activation) in the brains of Old mice. Five-week daily supplementation with CLA (650 mg/kg-1 body weight) of 16-week old mice (CLA+Old) diminished all the pathological hallmarks at a level comparable to Y mice or healthy controls (BALB/c). Such data demonstrated that MRL/lpr mice can serve as a valuable model for the evaluation of the effectiveness of neuroprotective drugs. Notably, the preventive effect provided by CLA supplementation against age-associated neuronal damage and hyperactivation of compensatory mechanisms suggests that the activation of an adaptive response is, at least in part, accountable for its neuroprotective ability.

Lingua abstract: inglese

Pagine da: 48

Pagine a: 57

Pagine totali: 10

Rivista:

Journal of lipid research American Society for Biochemistry and Molecular Biology
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0022-2275

Numero volume: 59

Numero fascicolo: 1

DOI: 10.1194/jlr.M079400.

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Parole chiave:

  • Antioxidants
  • conjugated Linoleic Acid
  • dietary lipids
  • Nrf2
  • adaptive response
  • neurodegeneration
  • MRL/lpr
  • oxidative stress

Data di accettazione: 15/12/2017

Strutture CNR:

 
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