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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2017

Contributo in rivista

Tipo: Articolo in rivista

Titolo: The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models

Anno di pubblicazione: 2017

Autori: Wolters, Maike; Dering, Carmen; Siani, Alfonso; Russo, Paola; Kaprio, Jaakko; Rise, Patrizia; Moreno, Luis A.; De Henauw, Stefaan; Mehlig, Kirsten; Veidebaum, Toomas; Molnar, Denes; Tornaritis, Michael; Iacoviello, Licia; Pitsiladis, Yannis; Galli, Claudio; Foraita, Ronja; Boernhorst, Claudia

Affiliazioni autori: 1 Leibniz Institute for Prevention Research and EpidemiologyđBIPS, Bremen, Germany, 2 Epidemiology and Population Genetics, Institute of Food Sciences, National Research Council, Avellino, Italy, 3 Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland, 4 DiSFeB, Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy, 5 GENUD (Growth, Exercise, Nutrition and Development) Research Group, Instituto Agroalimentario de Arago┬n (IA2), Instituto de Investigacio┬n Sanitaria Arago┬n (IIS Arago┬n), Centro de Investigacio┬n Biome┬dica en Red Fisiopatolog§┬a de la Obesidad y Nutricio┬n (CIBERObn), University of Zaragoza, Zaragoza, Spain, 6 Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium, 7 Section for Epidemiology and Social Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 8 National Institute for Health Development, Tallinn, Estonia, 9 National Institute of Health Promotion, University of Pe┬cs, Pe┬cs, Hungary, 10 Research and Education Institute of Child Health, Strovolos, Cyprus, 11 Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli (IS), Italy, 12 University of Brighton, Eastbourne, United Kingdom

Autori CNR:


Lingua: inglese

Abstract: Background The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP. Methods A subsample of the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) baseline survey including 520 children aged 2 to <10 years from six European countries was included. The association between rs174546 (TLingua abstract: inglese

Pagine totali: 17


PloS one Public Library of Science
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1932-6203

Numero volume: 12

Numero fascicolo: 7

DOI: 10.1371/journal.pone.0181485

Referee: Sý: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: ISI Web of Science (WOS) [000406643100040]

Parole chiave:

  • FADS1 polymorphism
  • children
  • BMI
  • fatty acids
  • blood pressure
  • path model

URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181485

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