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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2017

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Celiac disease: molecular basis

Anno di pubblicazione: 2017

Formato: Elettronico

Autori: Stefania Picascia, Alessandra Camarca, Carmen Gianfrani

Affiliazioni autori: Institute of Protein Biochemistry, CNR, Naples, Italy Institute of Food Sciences, CNR, Avellino, Italy

Autori CNR:

  • ALESSANDRA CAMARCA
  • CARMELA GIANFRANI
  • STEFANIA PICASCIA

Lingua: inglese

Abstract: Coeliac disease (CD) is an inflammatory and multifactorial disorder triggered by cereal gluten in genetically predisposed individuals. CD has several clinical and histological forms characterized by different grade of small intestinal inflammation. Several studies have demonstrated the key role of adaptive CD4+ T lymphocytes in gluten dependent enteropathy, although it has been clear that the intraepithelial CD8+ T lymphocytes of innate immunity, highly infiltrating CD mucosa, are pivotal in the induction of intestinal mucosa alteration and malfunction. Recent evidences also highlighted how adaptive CD8+ T lymphocytes restricted by HLA class I molecules contribute to the enterocytes damage through a TCR dependent cytotoxic activity. The recent findings on the involvement of HLA class I genes in CD susceptibility are also discussed.

Lingua abstract: inglese

Rivista:

eLS John Wiley & Sons Ltd, Chichester Wiley Online Library
Paese di pubblicazione: Regno Unito
Lingua: inglese

DOI: 10.1002/9780470015902.a0027650

Referee: Sė: Internazionale

Stato della pubblicazione: Preprint

Parole chiave:

  • Celiac disease
  • gluten
  • autoimmunity
  • cytotoxic CD8+ T lymphocytes
  • HLA class I

Strutture CNR:

 
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