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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2017

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Immune-modulating effects in mouse dendritic cells of lactobacilli and bifidobacteria isolated from individuals following omnivorous, vegetarian and vegan diets

Anno di pubblicazione: 2017

Formato: Elettronico

Autori: Luongo D.; Treppiccione L.; Sorrentino A.; Ferrocino I.; Turroni S.; Gatti M.; Di Cagno R.; Sanz Y.; Rossi M.

Affiliazioni autori: Institute of Food Sciences, CNR, Avellino, , Italy; Department of Agricultural, Forest and Food Science, University of Turin, Grugliasco, , Italy; Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Bologna, , Italy; Laboratory of Food Microbiology, Department of Food Science, University of Parma, Parco Area delle Scienze 48/A, Parma, , Italy; Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, , Italy; Microbial Ecology, Nutrition and Health Research Unit, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), Valencia, , Spain

Autori CNR:

  • DIOMIRA LUONGO
  • MAURO ROSSI
  • ALIDA SORRENTINO

Lingua: inglese

Abstract: Lactobacilli and bifidobacteria play a primary role in modulation of gut immunity. By considering that microbiota composition depends on various factors, including diet, we asked whether functional differences could characterize faecal populations of lactobacilli and bifidobacteria isolated from individuals with different dietary habits. 155 healthy volunteers who followed omnivorous, ovo-lacto-vegetarian or vegan diets were recruited at four Italian centres (Turin, Parma, Bologna and Bari). Faecal samples were collected; lactobacilli and bifidobacteria were isolated on selective media and their immunomodulatory activity was tested in mouse dendritic cells (DCs). Pre-incubation with lactobacilli increased LPS-induced expression of the maturation markers CD80 and CD86, whereas pre-incubation with bifidobacteria decreased such expression. Analysis of the cytokine profile indicated that strains of both genera induced down-regulation of IL-12 and up-regulation of IL-10, whereas expression of TNF-? was not modulated. Notably, analysis of anti-inflammatory potential (IL-10/IL-12 ratio) showed that lactobacilli evoked a greater anti-inflammatory effect than did bifidobacteria in the omnivorous group (P < 0.05). We also found significantly reduced anti-inflammatory potential in the bacterial strains isolated from Bari's volunteers in comparison with those from the cognate groups from the other centres. In conclusion, lactobacilli and bifidobacteria showed a genus-specific ability of modulating in vitro innate immunity associated with a specific dietary habit. Furthermore, the geographical area had a significant impact on the anti-inflammatory potential of some components of faecal microbiota.

Lingua abstract: inglese

Pagine da: 141

Pagine a: 148

Rivista:

Cytokine Saunders Scientific Publications, W.B. Saunders,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1043-4666

Numero volume: 97

DOI: 10.1016/j.cyto.2017.06.007

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: Scopus [2-s2.0-85021093227]

Parole chiave:

  • Dendritic cells; Immunity; Microbiota; Omnivorous diet; Vegan diet; Vegetarian diet

URL: http://www.scopus.com/record/display.url?eid=2-s2.0-85021093227&origin=inward

Strutture CNR:

 
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