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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Role of microRNAs in obesity and obesity-related diseases
Anno di pubblicazione: 2017
Autori: Iacomino G.; Siani A.
Affiliazioni autori: Institute of Food Sciences, CNR, Via Roma, 64, Avellino, 83100, , Italy
Abstract: In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in maintaining/altering physiological processes, including energy balance and metabolic homeostasis. Altered miRNAs expression has been reported in association with obesity, both in animal and human studies. Dysregulation of miRNAs may affect the status and functions of different tissues and organs, including the adipose tissue, pancreas, liver, and muscle, possibly contributing to metabolic abnormalities associated with obesity and obesity-related diseases. More recently, the discovery of circulating miRNAs easily detectable in plasma and other body fluids has emphasized their potential as both endocrine signaling molecules and disease indicators. In this review, the status of current research on the role of miRNAs in obesity and related metabolic abnormalities is summarized and discussed.
Lingua abstract: inglese
Genes & nutrition
Numero volume: 12
Referee: Sė: Internazionale
Stato della pubblicazione: Published version
Indicizzato da: Scopus [2-s2.0-85029867917]
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