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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2017

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Association of desaturase activity and C-reactive protein in European children

Anno di pubblicazione: 2017

Autori: Wolters, Maike; Boernhorst, Claudia; Schwarz, Heike; Rise, Patrizia; Galli, Claudio; Moreno, Luis A.; Pala, Valeria; Russo, Paola; Veidebaum, Toomas; Tornaritis, Michael; Fraterman, Arno; De Henauw, Stefaan; Eiben, Gabriele; Lissner, Lauren; Molnar, Denes; Ahrens, Wolfgang

Affiliazioni autori: 1Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany; 2DiSFeB, Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy; 3Growth, Exercise, Nutrition and Development (GENUD) Research Group, University of Zaragoza, Zaragoza, Spain; 4Epidemiology and Prevention Unit, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy; 5Epidemiology and Population Genetics, Institute of Food Sciences, National Research Council, Avellino, Italy; 6National Institute for Health Development, Tallinn, Estonia; 7Research and Education Institute of Child Health, Strovolos, Cyprus; 8Medizinisches Versorgungszentrum Dr. Eberhard und Partner Dortmund, Laboratoriumsmedizin, Dortmund, Germany; 9Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium; 10Section for Epidemiology and Social Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenberg, Sweden; 11National Institute of Health Promotion, University of Pécs, Pécs, Hungary; 12Institute of Statistics, Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany.

Autori CNR:


Lingua: inglese

Abstract: Background: Desaturase enzymes influence the fatty acid (FA) composition of body tissues and their activity affects the conversion rate of saturated to monounsaturated FA and of polyunsaturated FA (PUFA) to long-chain PUFA. Desaturase activity has further been shown to be associated with inflammation. We investigate the association between delta-9 (D9D), delta-6 (D6D) and delta-5 desaturase (D5D) activity and highsensitive C-reactive protein (CRP) in young children. Methods: In the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort study children were examined at baseline (T0) and after 2 y (T1). D9D, D6D, and D5D activities were estimated from T0 product-precursor FA ratios. CRP was measured at T0 and T1. In a subsample of 1,943 children with available information on FA, CRP, and covariates, the cross-sectional and longitudinal associations of desaturase activity and CRP were analyzed. Results: Cross-sectionally, a D9D increase of 0.01 units was associated with a 11% higher risk of having a serum CRP >= Percentile 75 (P75) (OR, 99% CI: 1.11 (1.01; 1.22)) whereas D6D and D5D were not associated with CRP. No significant associations were observed between baseline desaturase activity and CRP 2 y later. Conclusion: Cross-sectionally, our results indicate a positive association of D9D and CRP independent of weight status. High D9D activity may increase the risk of subclinical inflammation which is associated with metabolic disorders. As D9D expression increases with higher intake of saturated FA and carbohydrates, dietary changes may influence D9D activity and thus CRP. However, it remains to be investigated whether there is a causal relationship between D9D activity and CRP.

Lingua abstract: inglese

Pagine da: 27

Pagine a: 32

Pagine totali: 6


Pediatric research Nature Publishing Group
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0031-3998

Numero volume: 81

Numero fascicolo: 1

DOI: 10.1038/pr.2016.186

Referee: Sě: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: ISI Web of Science (WOS) [000391906800005]

Parole chiave:

  • Desaturase
  • C-reactive protein
  • children

URL: https://www.nature.com/articles/pr2016186

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