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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Blood fatty acid composition in relation to allergy in children aged 2-9 years: results from the European IDEFICS study
Anno di pubblicazione: 2017
Autori: Mikkelsen, A.; Galli, C.; Eiben, G.; Ahrens, W.; Iacoviello, L.; Molnar, D.; Pala, V.; Rise, P.; Rodriguez, G.; Russo, P.; Tornaritis, M.; Veidebaum, T.; Vyncke, K.; Wolters, M.; Mehlig, K.
Affiliazioni autori: 1Section for Epidemiology and Social Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 2Närhälsan, Research and Development Primary Health Care, Region Västra Götaland, Sweden; 3Department of Pharmacological and Biomolecular Sciences, DiSFeB, University of Milan, Milan, Italy; 4Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany; 5Laboratory of Molecular and Nutritional Epidemiology, Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli (IS), Italy; 6Department of Pediatrics, University of Pécs, Pécs, Hungary; 7Epidemiology Unit, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; 8GENUD (Growth, Exercise, Nutrition, and Development) Research Group, University of Zaragoza, Zaragoza, Spain; 9Instituto de Investigación Sanitaria, Aragón, Spain; 10Institute of Food Sciences, CNR, Avellino, Italy; 11Research and Education Institute of Child Health, Strovolos, Cyprus; 12National Institute for Health Development, Tallinn, Estonia and 13Department of Public Health, University of Ghent, Ghent, Belgium.
Abstract: BACKGROUND/OBJECTIVES: Blood polyunsaturated fatty acids (PUFA) are involved in allergy development, but the etiological role of n-6 and n-3 PUFA is still controversial. A European multicenter study of children (IDEFICS) provided the opportunity to explore the cross-sectional association between fatty acids (FA) and allergy. SUBJECTS/METHODS: Blood FA levels were measured in 2600 children aged 2-9 years and were recorded as the percentage of weight of all FA detected. Logistic regression of allergy status on FA components was adjusted for age, sex, country, body mass index, family history of allergic disease, breast-feeding, and number of siblings. The results were given as odds ratios (OR) for current vs no allergy ever and an increase in FA by 1 s.d. RESULTS: Overall, higher proportions of n-6 PUFA were associated with higher odds of allergy (OR = 1.21 (1.05, 1.40)). Monounsaturated FA (MUFA) were associated with reduced risk for allergy (OR = 0.75 (0.65, 0.87)), whereas saturated FA did not differ by allergy status. The strongest associations were observed in children o4 years old, with ORs of allergy given as 1.62 (1.15, 2.29) for n-3 PUFA and 0.63 (0.42, 0.95) for MUFA. With regard to individual FA, these associations were independently observed for docosapentaenoic acid (22:5 n-3) and oleic acid (18:1 n-9). CONCLUSIONS: Both PUFA subtypes were positively associated with allergy in an age-dependent manner, whereas MUFA was associated with less allergy. The observation of high proportions of n-3 PUFA in allergic children younger than 4 years might help to understand the nature of early onset of atopic disease.
Lingua abstract: inglese
Pagine da: 39
Pagine a: 44
Pagine totali: 6
European journal of clinical nutrition
Numero volume: 71
Numero fascicolo: 1
Referee: Sě: Internazionale
Stato della pubblicazione: Published version
Indicizzato da: ISI Web of Science (WOS) 
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