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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2017

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Vitamin D status and risk for malignant cutaneous melanoma: recent advances

Anno di pubblicazione: 2017

Formato: Elettronico

Autori: Ombra M.N.; Paliogiannis P.; Doneddu V.; Sini M.C.; Colombino M.; Rozzo C.; Stanganelli I.; Tanda F.; Cossu A.; Palmieri G.

Affiliazioni autori: aInstitute of Food Sciences, National Research Council (CNR), Avellino bDepartment of Surgical, Microsurgical and Medical Sciences, University of Sassari cInstitute of Biomolecular Chemistry, National Research Council (CNR), Cancer Genetics Unit, Sassari dRomagna Scientific Institute for the Study and Cure of Tumors, Skin Cancer Unit, Meldola, Italy

Autori CNR:

  • MARIA COLOMBINO
  • MARIA NEVE OMBRA
  • GIUSEPPE PALMIERI
  • CARLA MARIA ROZZO
  • MARIA CRISTINA SINI

Lingua: inglese

Abstract: Cutaneous malignant melanoma, whose incidence is increasing steadily worldwide, is the result of complex interactions between individual genetic factors and environmental risk factors. Ultraviolet radiation represents the most important environmental risk factor for the development of skin cancers, including melanoma. Sun exposure and early sunburn during childhood are the principal causes of cutaneous melanoma insurgence in adults, with double the risk relative to a nonexposed population. Consequently, ultraviolet protection has long been recognized as an important measure to prevent such a malignancy. Biological and epidemiological data suggest that vitamin D status could affect the risk of cancer and play a role in cancer prevention by exerting antiproliferative effects. Solar radiations are critical for vitamin D synthesis in humans; however, uncontrolled and intensive sun exposure is dangerous to skin health and may contribute toward the development of cutaneous malignant melanoma. An optimum balance between sun protection and exposure is thus advocated. Additional research is required to confirm the preventive role of vitamin D in melanoma incidence or a positive influence on patient outcome.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

Lingua abstract: inglese

Rivista:

European journal of cancer prevention Rapid Communications of Oxford,
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0959-8278

DOI: 10.1097/CEJ.0000000000000334

Stato della pubblicazione: Postprint

Indicizzato da: Scopus [2-s2.0-85010868145]

Parole chiave:

  • calcitriol
  • cancer
  • melanoma
  • skin
  • sun exposure
  • vitamin D

URL: http://www.scopus.com/record/display.url?eid=2-s2.0-85010868145&origin=inward

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