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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Associations of Whole Blood n-3 and n-6 Polyunsaturated Fatty Acids with Blood Pressure in Children and Adolescents - Results from the IDEFICS/I.Family Cohort.
Anno di pubblicazione: 2016
Autori: Maike Wolters1*, Valeria Pala2, Paola Russo3, Patrizia RisÚ4, Luis A. Moreno5, Stefaan De Henauw6, Kirsten Mehlig7, Toomas Veidebaum8, Dene┬s Molna┬ r9, Michael Tornaritis10, Claudio Galli4, Wolfgang Ahrens1,11, Claudia Bornhorst1, on behalf of the IDEFICS and I. Family consortia
Affiliazioni autori: 1 Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany, 2 Epidemiology and Prevention Unit, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy, 3 Epidemiology and Population Genetics, Institute of Food Sciences, National Research Council, Avellino, Italy, 4 DiSFeB, Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy, 5 GENUD (Growth, Exercise, Nutrition and Development) Research Group, Instituto Agroalimentario de Arago┬n (IA2), Instituto de Investigacio┬n Sanitaria Arago┬n (IIS Arago┬ n), Centro de Investigacio┬n Biome┬dica en Red Fisiopatolog§┬a de la Obesidad y Nutricio┬n (CIBERObn), University of Zaragoza, Zaragoza, Spain, 6 Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium, 7 Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 8 National Institute for Health Development, Tallinn, Estonia, 9 National Institute of Health Promotion, University of Pe┬cs, Pe┬cs, Hungary, 10 Research and Education Institute of Child Health, Nicosia, Cyprus, 11 Institute of Statistics, Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany
Abstract: Background Polyunsaturated n-3 and n-6 polyunsaturated fatty acids (PUFA) are precursors of biologically active metabolites that affect blood pressure (BP) regulation. This study investigated the association of n-3 and n-6 PUFA and BP in children and adolescents. Methods In a subsample of 1267 children aged 2▒9 years at baseline of the European IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort whole blood fatty acids were measured by a validated gas chromatographic method. Systolic and diastolic BP was measured at baseline and after two and six years. Mixed-effects models were used to assess the associations between fatty acids at baseline and BP z-scores over time adjusting for relevant covariables. Models were further estimated stratified by sex and weight status. Results The baseline level of arachidonic acid was positively associated with subsequent systolic BP (? = 0.08, P = 0.002) and diastolic BP (? = 0.07, P<0.001). In thin/normal weight children, baseline alpha-linolenic (? = -1.13, P = 0.003) and eicosapentaenoic acid (? = -0.85, P = 0.003) levels were inversely related to baseline and also to subsequent systolic BP and alpha-linolenic acid to subsequent diastolic BP. In overweight/obese children, baseline eicosapentaenoic acid level was positively associated with baseline diastolic BP (? = 0.54, P = 0.005). Conclusions Low blood arachidonic acid levels in the whole sample and high n-3 PUFA levels in thin/normal weight children are associated with lower and therefore healthier BP. The beneficial effects of high n-3 PUFA on BP were not observed in overweight/obese children, suggesting that they may have been overlaid by the unfavorable effects of excess weight.
Lingua abstract: inglese
Pagine totali: 17
Public Library of Science
Numero volume: 11
Referee: Sý: Internazionale
Stato della pubblicazione: Published version
Allegati: Associations of Whole Blood n-3 and n-6 Polyunsaturated Fatty Acids with Blood Pressure in Children and Adolescents ...
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