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Istituto di scienza dell'alimentazione

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Tipo: Articolo in rivista

Titolo: Effect of Lactobacillus paracasei Culture Filtrates and Artichoke Polyphenols on Cytokine Production by Dendritic Cells

Anno di pubblicazione: 2016

Formato: Elettronico

Autori: Angelo Sisto1,*, Diomira Luongo2, Lucia Treppiccione 2, Palmira De Bellis1, Donato Di Venere1, Paola Lavermicocca1 and Mauro Rossi2

Affiliazioni autori: 1Institute of Sciences of Food Production (ISPA), National Research Council (CNR), Via Amendola 122/O, Bari 70126, Italy; 2Institute of Food Sciences (ISA), National Research Council (CNR), Via Roma 52, Avellino 83100, Italy;

Autori CNR:

  • PALMIRA DE BELLIS
  • DONATO DI VENERE
  • PAOLA LAVERMICOCCA
  • DIOMIRA LUONGO
  • MAURO ROSSI
  • ANGELO SISTO
  • LUCIA TREPPICCIONE

Lingua: inglese

Abstract: The most recent trend in research on probiotic bacteria aims at the exploitation of bioactive bacterial compounds that are responsible for health-promoting effects and suitable for medical applications. Therefore, the main purpose of this study was to ascertain if the immunomodulatory effects of L. paracasei strains on dendritic cells (DCs) were caused by bacterial metabolites released in the culture medium. For that reason, bacterial strains were grown in two media generally used for the culture of DCs, and the effects of culture filtrates on the maturation of DCs and cytokine production were evaluated. Moreover, to reveal potential synergistic effects on the immunomodulation of DCs, an artichoke phenolic extract (APE) was added to the media before bacterial growth. The experiments pointed out an interesting anti-inflammatory activity of a culture filtrate obtained after growing a probiotic L. paracasei strain in one of the media supplemented with APE. Therefore, this culture filtrate--which combines the anti-inflammatory activity and the other well-known health-promoting properties of artichoke phenolic compounds--could represent the basis for future particular exploitations.

Lingua abstract: inglese

Pagine da: 635

Pagine totali: 12

Rivista:

Nutrients MDPI
Paese di pubblicazione:
Lingua: inglese
ISSN: 2072-6643

Numero volume: 8

DOI: 10.3390/nu8100635

Referee: Ś: Internazionale

Stato della pubblicazione: Published version

Indicizzato da:

  • ISI Web of Science (WOS) [27754398]
  • Scopus [2-s2.0-84991643980]

Parole chiave:

  • probiotic bacteria; immunomodulatory bacterial metabolites; dendritic cells; artichoke phenolic compounds

Data di accettazione: 28/09/2016

Strutture CNR:

Moduli:

Allegati: Effect of Lactobacillus paracasei Culture Filtrates and Artichoke Polyphenols on Cytokine Production by Dendritic Cells (application/pdf)
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