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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2016

Contributo in rivista

Tipo: Articolo in rivista

Titolo: A theoretical study on predicted protein targets of apple polyphenols and possible mechanisms of chemoprevention in colorectal cancer

Anno di pubblicazione: 2016

Formato: Elettronico

Autori: Scafuri, Bernardina; Scafuri, Bernardina; Marabotti, Anna; Marabotti, Anna; Carbone, Virginia; Minasi, Paola; Dotolo, Serena; Facchiano, Angelo

Affiliazioni autori: Consiglio Nazionale delle Ricerche; Universita di Salerno

Autori CNR:

  • VIRGINIA CARBONE
  • ANGELO FACCHIANO
  • PAOLA MINASI

Lingua: inglese

Abstract: We investigated the potential role of apple phenolic compounds in human pathologies by integrating chemical characterization of phenolic compounds in three apple varieties, computational approaches to identify potential protein targets of the compounds, bioinformatics analyses on data from public archive of gene expression data, and functional analyses to hypothesize the effects of the selected compounds in molecular pathways. Starting by the analytic characterization of phenolic compounds in three apple varieties, i.e. Annurca, Red Delicious, and Golden Delicious, we used computational approaches to verify by reverse docking the potential protein targets of the identified compounds. Direct docking validation of the potential protein-ligand interactions has generated a short list of human proteins potentially bound by the apple phenolic compounds. By considering the known chemo-preventive role of apple antioxidants' extracts against some human pathologies, we performed a functional analysis by comparison with experimental gene expression data and interaction networks, obtained from public repositories. The results suggest the hypothesis that chemo-preventive effects of apple extracts in human pathologies, in particular for colorectal cancer, may be the interference with the activity of nucleotide metabolism and methylation enzymes, similarly to some classes of anticancer drugs.

Lingua abstract: inglese

Rivista:

Scientific reports Nature Publishing Group
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 2045-2322

Numero volume: 6

DOI: 10.1038/srep32516

Stato della pubblicazione: Published version

Indicizzato da: Scopus [2-s2.0-84985911661]

Parole chiave:

  • antioxidants

URL: http://www.scopus.com/record/display.url?eid=2-s2.0-84985911661&origin=inward

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