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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Whole-blood fatty acids and inflammation in European children: the IDEFICS Study.
Anno di pubblicazione: 2016
Autori: Gonzalez-Gil E.M.; Santabarbara J.; Siani A.; Ahrens W.; Sioen I.; Eiben G.; Gunther K.; Iacoviello L.; Molnar D.; Rise P.; Russo P.; Tornaritis M.; Veidebaum T.; Galli C.; Moreno L.A.
Affiliazioni autori: GENUD (Growth, Exercise, NUtrition and Development) Research Group, Faculty of Health Sciences, University of Zaragoza, Zaragoza, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain; Department of Preventive Medicine and Public Health, University of Zaragoza, Zaragoza, Spain; Unit of Epidemiology and Population Genetics, Institute of Food Sciences, National Research Council, Avellino, Italy; Department of Epidemiological Methods and Etiologic Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany; Institute of Statistics, Faculty of Mathematics and Computer Science, University Bremen, Bremen, Germany; Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium; Department of Community Medicine and Public Health, Sahlgrenska Academy at Göteborg University, Gothenburg, Sweden; Laboratory of Molecular and Nutritional Epidemiology, Department of Epidemiology and Prevention, IRCCS Mediterranean Neurological Institute NEUROMED, Pozzilli, Italy; Department of Paediatrics, Medical Faculty, University of Pécs, Pécs, Hungary; Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy; Research and Education Institute of Child Health, REF, Strovolos, Cyprus and National Institute for Health Development, Tervise Arengu Instituut, Tallinn, Estonia.
Abstract: Background/Objectives:Fatty acids are hypothesized to influence cardiovascular disease risk because of their effect on inflammation. The aim of this study is to assess the relationship between whole-blood fatty acids (WBFAs) and high-sensitivity C-reactive protein (hs-CRP) in European children.Subjects/Methods:A total of 1401 subjects (697 boys and 704 girls) aged between 2 and 9 years from the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects in Children and infantS) study were measured in this cross-sectional analysis. The sample was divided into three categories of hs-CRP. Associations between WBFA and hs-CRP were assessed by logistic regression models adjusting for body mass index (BMI), country, age, breastfeeding, mother's education and hours of physical activity.Results:Linoleic acid (LA) (P=0.013, 95% confidence interval (CI): 0.822-0.977) and sum of n-6 WBFA (P=0.029, 95% CI: 0.866-0.992) concentrations were associated with lower concentrations of hs-CRP in boys. In girls, a high ratio of eicosapentaenoic acid (EPA)/arachidonic acid (AA) was associated (P=0.018, 95% CI: 0.892-0.989) with lower hs-CRP concentrations. In contrast, sum of blood n-6 highly unsaturated fatty acids (P=0.012, 95% CI: 1.031-1.284), AA (P=0.007, 95% CI: 1.053-1.395) and AA/LA ratio (P=0.005, 95% CI: 1.102-1.703) were associated (P<0.05) with higher concentrations of hs-CRP in girls.Conclusions:The n-6 WBFAs (sum of n-6 FA and LA) were associated with lower hs-CRP in boys and with higher hs-CRP in girls (AA, sum of n-6 highly unsaturated and AA/LA ratio). More studies are needed to identify the optimal levels of WBFAs to avoid low-grade inflammation in children considering the differences by sex and BMI.European Journal of Clinical Nutrition advance online publication, 13 January 2016; doi:10.1038/ejcn.2015.219.
Lingua abstract: inglese
Pagine da: 819
Pagine a: 823
Pagine totali: 5
European journal of clinical nutrition
Numero volume: 70
Numero fascicolo: 7
Referee: Sě: Internazionale
Stato della pubblicazione: Published version
Indicizzato da: Scopus [2-s2.0-84954350089]
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