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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2015

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis

Anno di pubblicazione: 2015

Formato: Elettronico Cartaceo

Autori: Gardi C.; Bauerova K.; Stringa B.; Kuncirova V.; Slovak L.; Ponist S.; Drafi F.; Bezakova L.; Tedesco I.; Acquaviva A.; Bilotto S.; Russo G.L.

Affiliazioni autori: Institute of Food Sciences, National Research Council, Via Roma 64, Avellino, 83100, Italy; Department of Molecular and Developmental Medicine, University of Siena, Via A. Moro 2, Siena, I-53100, Italy; Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dubravska Cesta 9, Bratislava, SK-841 04, Slovakia; Faculty of Pharmacy, Comenius University, Bratislava, Slovakia

Autori CNR:

  • STEFANIA BILOTTO
  • GIAN LUIGI RUSSO
  • IDOLO TEDESCO

Lingua: inglese

Abstract: Novel therapies for rheumatoid arthritis also include the use of naturally occurring compounds possessing antioxidant properties. In the present work, the effects of oral administration of quercetin were investigated in a rat model of adjuvant arthritis. Arthritis was induced by a single intradermal injection of heat-inactivated Mycobacterium butyricum in incomplete Freund's adjuvant. The experimental groups were treated with an oral daily dose of 150 mg/kg b.w. of quercetin for 28 days. Results indicated that quercetin was able to ameliorate all markers of inflammation and oxidative stress measured. Quercetin lowered levels of interleukin-1?, C-reactive protein, and monocyte chemotactic protein-1 and restored plasma antioxidant capacity. In addition, quercetin inhibited the enzymatic activity of pro-inflammatory 12/15-lipoxygenase in lung and liver and increased the expression of heme oxygenase-1 in joint and lung of arthritic rats. Finally, quercetin inhibited the 2-fold increase of NF-?B activity observed in lung, liver and joint after induction of arthritis.

Lingua abstract: inglese

Pagine da: 150

Pagine a: 157

Pagine totali: 7

Rivista:

Archives of biochemistry and biophysics Elsevier Inc.
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0003-9861

Numero volume: 583

DOI: 10.1016/j.abb.2015.08.008

Referee: Sì: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: Scopus [2-s2.0-84942104615]

Parole chiave:

  • Adjuvant arthritis
  • ERK pathway
  • Inflammation
  • NF-?B
  • Oxidative stress
  • Quercetin

URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84942104615&partnerID=q2rCbXpz

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