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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2015

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Designing a broad-spectrum integrative approach for cancer prevention and treatment

Anno di pubblicazione: 2015

Formato: Elettronico Cartaceo

Autori: Keith I. Blocka,*, Charlotte Gyllenhaala, Leroy Loweb,er,**, Amedeo Amedeic, A.R.M. Ruhul Amind, Amr Amine, Katia Aquilanof, Jack Arbiserd,ep,eq, Alexandra Arreolag, Alla Arzumanyanh, S. Salman Ashrafi, Asfar S. Azmij, Fabian Benenciak, Dipita Bhaktal, Alan Bilslandm, Anupam Bishayeen, Stacy W. Blaino, Penny B. Blocka, Chandra S. Boosanip, Thomas E. Careyq, Amancio Carneror, Marianeve Carotenutos,t, Stephanie C. Caseyu, Mrinmay Chakrabartiv, Rupesh Chaturvediw, Georgia Zhuo Chend, Helen Chenx, Sophie Cheny, Yi Charlie Chenz, Beom K. Choiaa, Maria Rosa Ciriolo f, Helen M. Coleyab, Andrew R. Collins ac, Marisa Connellx, Sarah Crawfordad, Colleen S. Curranae, Charlotta Dabrosinaf, Giovanna Damiaag, Santanu Dasguptaah, Ralph J. DeBerardinisaj, William K. Deckerak, Punita Dhawanal, Anna Mae E. Diehlam, Jin-Tang Dongd, Q. Ping Douj, Janice E. Drewan, Eyad Elkordao, Bassel El-Rayesap, Mark A. Feitelsonh, Dean W. Felsheru, Lynnette R. Fergusonaq, Carmela Fimognariar, Gary L. Firestoneas, Christian Frezzaat, Hiromasa Fujii au, Mark M. Fusterav, Daniele Generaliaw,ax, Alexandros G. Georgakilasay, Frank Gieseleraz, Michael Gilbertsonba, Michelle F. Greenbb, Brendan Gruebc, Gunjan Guhal, Dorota Halickabd, William G. Helferichbe, Petr Henebergbf, Patricia Hentoshbg, Matthew D. Hirscheyam,bb, Lorne J. Hofsethbh, Randall F. Holcombebi, Kanya Honokiau, Hsue-Yin Hsubj, Gloria S. Huangbk, Lasse D. Jensenbl,bm, Wen G. Jiangbn, Lee W. Jonesbo, Phillip A. Karpowiczbp, W. Nicol Keithm, Sid P. Kerkarbq, Gazala N. Khanbr, Mahin Khatamibs, Young H. Kobt, Omer Kucukd, Rob J. Kulathinalh, Nagi B. Kumarbu, Byoung S. Kwonaa,bw, Anne Lebx, Michael A. Leaby, Ho-Young Leebz, Terry Lichtorca, Liang-Tzung Lincb, Jason W. Locasalecc, Bal L. Lokeshwarcd, Valter D. Longoce, Costas A. Lyssiotis cf, Karen L. MacKenziecg, Meenakshi Malhotrach, Maria Marinoci, Maria L. Martinez-Chantarcj, Ander Matheuck, Christopher Maxwellx, Eoin McDonnellbb, Alan K. Meekercl, Mahya Mehrmohamadicm, Kapil Mehtacn, Gregory A. Michelottiam, Ramzi M. Mohammadj, Sulma I. Mohammedco, D. James Morrecp, Irfana Muqbilj, Vinayak Muralidharcq,cr, Michael P. Murphycs, Ganji Purnachandra Nagarajuap, Rita Nahtad, Elena Niccolaict, Somaira Nowsheencu, Carolina Paniscv, Francesco Pantanocw, Virginia R. Parslowaq, Graham Paweleccx, Peter L. Pedersency, Brad Poorebx, Deepak Poudyalbh, Satya Prakashch, Mark Princecz, Lizzia Raffaghelloda, Jeffrey C. Rathmellbb, W. Kimryn Rathmellg, Swapan K. Rayv, Jörg Reichrathdb, Sarallah Rezazadehdc, Domenico Ribatti dd, Luigi Ricciardiello de, R. Brooks Robeydf,dg, Francis Rodierdh,di, H.P. Vasantha Rupasinghedj, Gian Luigi Russodk, Elizabeth P. Ryandl, Abbas K. Samadidm, Isidro Sanchez-Garciadn, Andrew J. Sandersbn, Daniele Santinicw, Malancha Sarkardo, Tetsuro Sasadadp, Neeraj K. Saxenadq, Rodney E. Shackelforddr, H.M.C. Shantha Kumarabv, Dipali Sharmads, Dong M. Shind, David Sidranskydt, Markus David Siegelindu, Emanuela Signoridv, Neetu Singhdw, Sharanya Sivananddx, Daniel Sliva dy, Carl Smythedz, Carmela Spagnuolodk, Diana M. Stafforini ea, John Staggeb, Pochi R. Subbarayanec, Tabetha Sundined, Wamidh H. Talibee, Sarah K. Thompsonef, Phuoc T. Traneg, Hendrik Ungefrorenaz, Matthew G. Vander Heidencr, Vasundara Venkateswaraneh, Dass S. Vinayai, Panagiotis J. Vlachostergiosei, Zongwei Wangej, Kathryn E. Wellendx, Richard L. Whelanbv, Eddy S. Yangek, Huanjie Yangel, Xujuan Yangbe, Paul Yaswenem, Clement Yedjouen, Xin Yinav, Jiyue Zhueo, Massimo Zollos,t

Affiliazioni autori: a Block Center for Integrative Cancer Treatment, Skokie, IL, United States b Getting to Know Cancer, Truro, Nova Scotia, Canada c Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy d Winship Cancer Institute of Emory University, Atlanta, GA, United States e Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates f Department of Biology, University of Rome "Tor Vergata", Rome, Italy g Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States h Department of Biology, Temple University, Philadelphia, PA, United States i Department of Chemistry, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates j Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, United States k Department of Biomedical Sciences, Ohio University, Athens, OH, United States l School of Chemical and Bio Technology, SASTRA University, Thanjavur, Tamil Nadu, India m University of Glasgow, Glasgow, United Kingdom n Department of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, Miami, FL, United States o Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn, NY, United States p Department of BioMedical Sciences, School of Medicine, Creighton University, Omaha, NE, United States q Head and Neck Cancer Biology Laboratory, University of Michigan, Ann Arbor, MI, United States r Instituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Cientificas, Seville, Spain s Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy t Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy u Stanford University, Division of Oncology, Department of Medicine and Pathology, Stanford, CA, United States v Department of Pathology, Microbiology, and Immunology, University of South Carolina, School of Medicine, Columbia, SC, United States w School of Biotechnology, Jawaharlal Nehru University, New Delhi, India x Department of Pediatrics, University of British Columbia, Michael Cuccione Childhood Cancer Research Program, Child and Family Research Institute, Vancouver, British Columbia, Canada y Ovarian and Prostate Cancer Research Laboratory, Guildford, Surrey, United Kingdom z Department of Biology, Alderson Broaddus University, Philippi, WV, United States aa Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Goyang, Gyeonggi, Republic of Korea ab Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, United Kingdom ac Department of Nutrition, Faculty of Medicine, University of Oslo, Oslo, Norway ad Cancer Biology Research Laboratory, Southern Connecticut State University, New Haven, CT, United States ae School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States af Department of Oncology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden ag Department of Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy ah Department of Cellular and Molecular Biology, the University of Texas Health Science Center at Tyler, Tyler, TX, United States ai Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, United States aj Children's Medical Center Research Institute, University of Texas - Southwestern Medical Center, Dallas, TX, United States ak Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, United States al Department of Surgery and Cancer Biology, Division of Surgical Oncology, Vanderbilt University School of Medicine, Nashville, TN, United States am Department of Medicine, Duke University Medical Center, Durham, NC, United States an Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, Scotland, United Kingdom ao College of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates ap Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, United States aq Discipline of Nutrition and Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand ar Dipartimento di Scienze per la Qualità della Vita Alma Mater Studiorum-Università di Bologna, Rimini, Italy as Department of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, United States at Medical Research Council Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, United Kingdom au Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara, Japan av Medicine and Research Services, Veterans Affairs San Diego Healthcare System & University of California, San Diego, CA, United States aw Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy ax Molecular Therapy and Pharmacogenomics Unit, Azienda Ospedaliera Istituti Ospitalieri di Cremona, Cremona, Italy ay Physics Department, School of Applied Mathematics and Physical Sciences, National Technical University of Athens, Athens, Greece az First Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany ba Getting to Know Cancer, Guelph, Canada bb Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, United States bc Departments of Environmental Science, Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada bd Department of Pathology, New York Medical College, Valhalla, NY, United States be University of Illinois at Urbana Champaign, Champaign, IL, United States bf Charles University in Prague, Third Faculty of Medicine, Prague, Czech Republic bg School of Medical Laboratory and Radiation Sciences, Old Dominion University, Norfolk, VA, United States bh College of Pharmacy, University of South Carolina, Columbia, SC, United States bi Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, United States bj Department of Life Sciences, Tzu-Chi University, Hualien, Taiwan bk Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States bl Department of Medical and Health Sciences, Linköping University, Linköping, Sweden bm Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden bn Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom bo Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, United States bp University of Windsor, Windsor, Ontario, Canada bq Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States br Henry Ford Hospital, Detroit, MI, United States bs Inflammation and Cancer Research, National Cancer Institute (Retired), National Institutes of Health, Bethesda, MD, United States bt University of Maryland BioPark, Innovation Center, KoDiscovery, Baltimore, MD, United States bu Moffitt Cancer Center, University of South Florida College of Medicine, Tampa, FL, United States bv Department of Surgery, St. Luke's Roosevelt Hospital, New York, NY, United States bw Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, United States bx The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States by New Jersey Medical School, Rutgers University, Newark, NJ, United States bz College of Pharmacy, Seoul National University, South Korea ca Department of Neurosurgery, Rush University Medical Center, Chicago, IL, United States cb Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan cc Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States cd Department of Medicine, Georgia Regents University Cancer Center, Augusta, GA, United States ce Andrus Gerontology Center, Division of Biogerontology, University of Southern California, Los Angeles, CA, United States cf Department of Molecular and Integrative Physiology and Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, United States cg Children's Cancer Institute Australia, Kensington, New South Wales, Australia ch Department of Biomedical Engineering, McGill University, Montréal, Canada ci Department of Science, University Roma Tre, Rome, Italy cj Metabolomic Unit, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Technology Park of Bizkaia, Bizkaia, Spain ck Biodonostia Institute, Gipuzkoa, Spain cl Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States cm Field of Genetics, Genomics, and Development, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, United States cn Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, United States co Department of Comparative Pathobiology, Purdue University Center for Cancer Research, West Lafayette, IN, United States cp Mor-NuCo, Inc, Purdue Research Park, West Lafayette, IN, United States cq Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, United States cr Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States cs MRC Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Hills Road, Cambridge, United Kingdom ct University of Florence, Florence, Italy cu Medical Scientist Training Program, Mayo Graduate School, Mayo Medical School, Mayo Clinic, Rochester, MN, United States cv Laboratory of Inflammatory Mediators, State University of West Paraná, UNIOESTE, Paraná, Brazil cw Medical Oncology Department, University Campus Bio-Medico, Rome, Italy cx Center for Medical Research, University of Tübingen, Tübingen, Germany cy Departments of Biological Chemistry and Oncology, Member at Large, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD, United States cz Department of Otolaryngology-Head and Neck, Medical School, University of Michigan, Ann Arbor, MI, United States da Laboratory of Oncology, Istituto Giannina Gaslini, Genoa, Italy db Center for Clinical and Experimental Photodermatology, Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, Homburg, Germany dc Department of Biology, University of Rochester, Rochester, NY, United States dd Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy & National Cancer Institute Giovanni Paolo II, Bari, Italy de Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy df White River Junction Veterans Affairs Medical Center, White River Junction, VT, United States dg Geisel School of Medicine at Dartmouth, Hanover, NH, United States dh Centre de Recherche du Centre Hospitalier de l'Université de Montréal and Institut du Cancer de Montréal, Montréal, Quebec, Canada di Université de Montréal, Département de Radiologie, Radio-Oncologie et Médicine Nucléaire, Montréal, Quebec, Canada dj Department of Environmental Sciences, Faculty of Agriculture and Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada dk Institute of Food Sciences National Research Council, Avellino, Italy dl Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, United States dm Sanus Biosciences, San Diego, CA, United States dn Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC-Universidad de Salamanca, Salamanca, Spain do Department of Biology, University of Miami, Miami, FL, United States dp Department of Immunology, Kurume University School of Medicine, Kurume, Fukuoka, Japan dq Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States dr Department of Pathology, Louisiana State University, Health Shreveport, Shreveport, LA, United States ds Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, United States dt Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States du Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, United States dv National Research Council, Institute of Translational Pharmacology, Rome, Italy dw Advanced Molecular Science Research Centre (Centre for Advanced Research), King George's Medical University, Lucknow, Uttar Pradesh, India dx Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States dy DSTest Laboratories, Purdue Research Park, Indianapolis, IN, United States dz Department of Biomedical Science, Sheffield Cancer Research Centre, University of Sheffield, Sheffield, United Kingdom ea Huntsman Cancer Institute and Department of Internal Medicine, University of Utah, Salt Lake City, UT, United States eb Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Faculté de Pharmacie et Institut du Cancer de Montréal, Montréal, Quebec, Canada ec Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States ed Department of Molecular Diagnostics, Sentara Healthcare, Norfolk, VA, United States ee Department of Clinical Pharmacy and Therapeutics, Applied Science University, Amman, Jordan

Autori CNR:

  • GIAN LUIGI RUSSO
  • CARMELA SPAGNUOLO

Lingua: inglese

Abstract: Despite exciting advances in targeted therapies, high drug costs, marginal therapeutic benefits and notable toxicities are concerning aspects of today's cancer treatments. This special issue of Seminars in Cancer Biology proposes a broad-spectrum, integrative therapeutic model to complement targeted therapies. Based on extensive reviews of the cancer hallmarks, this model selects multiple high-priority targets for each hallmark, to be approached with combinations of low-toxicity, low-cost therapeutics, including phytochemicals, adapted to the well-known complexity and heterogeneity of malignancy. A global consortium of researchers has been assembled to advance this concept, which is especially relevant in an era of rapidly expanding capacity for genomic tumor analyses, alongside alarming growth in cancer morbidity and mortality in low- and middle-income nations.

Lingua abstract: inglese

Pagine da: S276

Pagine a: S304

Pagine totali: 28

Rivista:

Seminars in cancer biology Saunders Scientific Publications,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1044-579X

Numero volume: 35

DOI: 10.1016/j.semcancer.2015.08.002

Referee: Sì: Internazionale

Stato della pubblicazione: Preprint

Indicizzato da: Scopus [2-s2.0-84941248118]

Parole chiave:

  • Broad-spectrum
  • Phytochemicals
  • Targeted therapies
  • Therapeutic resistance

URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84941248118&partnerID=q2rCbXpz

Strutture CNR:

Moduli:

Allegati: Designing a broad-spectrum integrative approach for cancer prevention and treatment (application/pdf)

 
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