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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2015

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials

Anno di pubblicazione: 2015

Formato: Elettronico Cartaceo

Autori: Nabavi S.F.; Bilotto S.; Russo G.L.; Orhan I.E.; Habtemariam S.; Daglia M.; Devi K.P.; Loizzo M.R.; Tundis R.; Nabavi S.M.

Affiliazioni autori: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; National Research Council, Institute of Food Sciences, Avellino, 83100, Italy; Department of Pharmacognosy, Gazi University, Ankara, 06330, Turkey; Pharmacognosy Research Laboratories, Medway School of Science, University of Greenwich, Chatham-Maritime, Kent, ME4 4TB, United Kingdom; Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Via Taramelli 12, Pavia, 27100, Italy; Department of Biotechnology, Alagappa University, Karaikudi, Tamil Nadu, 630 004, India; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, CS, 87036, Italy

Autori CNR:

  • STEFANIA BILOTTO
  • GIAN LUIGI RUSSO

Lingua: inglese

Abstract: Over the past decades, extensive studies have addressed the therapeutic effects of omega-3 polyunsaturated fatty acids (omega-3 FAs) against different human diseases such as cardiovascular and neurodegenerative diseases, cancer, etc. A growing body of scientific research shows the pharmacokinetic information and safety of these natural occurring substances. Moreover, during recent years, a plethora of studies has demonstrated that omega-3 FAs possess therapeutic role against certain types of cancer. It is also known that omega-3 FAs can improve efficacy and tolerability of chemotherapy. Previous reports showed that suppression of nuclear factor-?B, activation of AMPK/SIRT1, modulation of cyclooxygenase (COX) activity, and up-regulation of novel anti-inflammatory lipid mediators such as protectins, maresins, and resolvins, are the main mechanisms of antineoplastic effect of omega-3 FAs. In this review, we have collected the available clinical data on the therapeutic role of omega-3 FAs against breast cancer, colorectal cancer, leukemia, gastric cancer, pancreatic cancer, esophageal cancer, prostate cancer, lung cancer, head and neck cancer, as well as cancer cachexia. We also discussed the chemistry, dietary source, and bioavailability of omega-3 FAs, and the potential molecular mechanisms of anticancer and adverse effects.

Lingua abstract: inglese

Pagine da: 359

Pagine a: 380

Rivista:

Cancer metastasis reviews Kluwer Academic Publishers
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 0167-7659

Numero volume: 34

Numero fascicolo: 3

DOI: 10.1007/s10555-015-9572-2

Referee: Sì: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: Scopus [2-s2.0-84942197192]

Parole chiave:

  • Cancer
  • Clinical trials
  • Nuclear factor-?B
  • Omega-3 FA

URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84942197192&partnerID=q2rCbXpz

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