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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2015

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Dietary Polyphenols and Chromatin Remodelling

Anno di pubblicazione: 2015

Formato: Elettronico Cartaceo

Autori: Gian Luigi Russo, Viviana Vastolo, Marco Ciccarelli, Luigi Albano, Paolo Emidio Macchia & Paola Ungaro

Affiliazioni autori: 1) Istituto di Scienze dell"Alimentazione, Consigio Nazionale delle Ricerche, 83100, Avellino, Italy 2) Dipartimento di Scienze Mediche Traslazionali, Università degli Studi di Napoli ,,Federico II", Napoli, Italy. 3) Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli ,,Federico II", Napoli, Italy 4) Istituto di Endocrinologia ed Oncologia Sperimentale ,,G. Salvatore", Consiglio Nazionale delle Ricerche, 80131, Napoli, Italy

Autori CNR:


Lingua: inglese

Abstract: Polyphenols are the most abundant phytochemicals in fruits, vegetables and plant-derived beverages. Recent findings suggest that polyphenols display the ability to reverse adverse epigenetic regulation involved in pathological conditions, such as obesity, metabolic disorder, cardiovascular and neurodegenerative diseases and various forms of cancer. Epigenetics, defined as heritable changes to the transcriptome, independent from those occurring in the genome, includes DNA methylation, histone modifications, and post transcriptional gene regulation by non-coding RNAs. Sinergistically and cooperatively these processes regulate gene expression by changing chromatin organization and DNA accessibility. Such induced epigenetic changes can be inherited during cell division, resulting in permanent maintenance of the acquired phenotype, but they may also occur throughout an individual life-course and may ultimately influence phenotypic outcomes (health and disease risk). In the last decade, a number of studies have shown that nutrients can affect metabolic traits by altering the structure of chromatin and directly regulate both transcription and translational processes. In this context, dietary polyphenoltargeted epigenetics becomes an attractive approach for disease prevention and intervention. Here, we will review how polyphenols, including flavonoids, curcuminoids and stilbenes, modulate the establishment and maintenance of key epigenetic marks, thereby influencing gene expression and, hence, disease risk and health.

Lingua abstract: inglese


Critical reviews in food science and nutrition CRC Press,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1040-8398

DOI: 10.1080/10408398.2015.1062353

Referee: Sì: Internazionale

Stato della pubblicazione: Published version

Parole chiave:

  • DNA methylation; Histone modifications
  • MicroRNA; Epigenome.

URL: http://www.tandfonline.com/loi/bfsn20

Strutture CNR:


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