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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2015

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Lactobacillus acidophilus-Rutin Interplay Investigated by Proteomics

Anno di pubblicazione: 2015

Formato: Elettronico

Autori: Mazzeo MF, Lippolis R, Sorrentino A, Liberti S, Fragnito F, Siciliano RA

Affiliazioni autori: Institute of Food Sciences, National Research Council (ISA-CNR), Avellino, Italy Institute of Biomembranes and Bioenergetics, National Research Council (IBBE-CNR), Bari, Italy Department of Chemical Sciences, University of Naples Federico II, Naples, Italy

Autori CNR:

  • ROSA LIPPOLIS
  • MARIA FIORELLA MAZZEO
  • ROSA ANNA SICILIANO
  • ALIDA SORRENTINO

Lingua: inglese

Abstract: Dietary polyphenols are bioactive molecules that beneficially affect human health, due to their anti-oxidant, anti-inflammatory, cardio-protective and chemopreventive properties. They are absorbed in a very low percentage in the small intestine and reach intact the colon, where they are metabolized by the gut microbiota. Although it is well documented a key role of microbial metabolism in the absorption of polyphenols and modulation of their biological activity, molecular mechanisms at the basis of the bacteria-polyphenols interplay are still poorly understood. In this context, differential proteomics was applied to reveal adaptive response mechanisms that enabled a potential probiotic Lactobacillus acidophilus strain to survive in the presence of the dietary polyphenol rutin. The response to rutin mainly modulated the expression level of proteins involved in general stress response mechanisms and, in particular, induced the activation of protein quality control systems, and affected carbohydrate and amino acid metabolism, protein synthesis and cell wall integrity. Moreover, rutin triggered the expression of proteins involved in oxidation-reduction processes.This study provides a first general view of the impact of dietary polyphenols on metabolic and biological processes of L. acidophilus

Lingua abstract: inglese

Pagine da: e0142376

Rivista:

PloS one Public Library of Science
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1932-6203

Numero volume: 10

Numero fascicolo: 11

DOI: 10.1371/journal.pone.0142376

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: PubMed [26544973]

Parole chiave:

  • lactobacilli; L. acidophilus; polyphenols; rutin; probiotics; proteomics; stress response; adaptive response

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