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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2015

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Desaturase Activity Is Associated With Weight Status and Metabolic Risk Markers in Young Children.

Anno di pubblicazione: 2015

Formato: Elettronico

Autori: Maike Wolters, Heike Schlenz, Claudia Börnhorst, Patrizia Risé, Claudio Galli, Luis A. Moreno, Valeria Pala, Alfonso Siani, Toomas Veidebaum, Michael Tornaritis, Arno Fraterman, Stefaan de Henauw, Staffan Marild, Denes Molnar, and Wolfgang Ahrens, and on behalf of the IDEFICS consortium

Affiliazioni autori: 1 Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany; 2 DiSFeB, Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy; 3 Growth, Exercise, Nutrition and Development (GENUD) Research Group, University of Zaragoza, Zaragoza, Spain; 4 Epidemiology and Prevention Unit, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy; 5 Epidemiology and Population Genetics, Institute of Food Sciences, National Research Council, Avellino, Italy; 6 National Institute for Health Development, Tallinn, Estonia; 7 Research and Education Institute of Child Health, Strovolos, Cyprus; 8 Medizinisches Versorgungszentrum Dr. Eberhard und Partner Dortmund, Laboratoriumsmedizin, Dortmund, Germany; 9 Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium; 10 Department of Public Health and Community Medicine, Queen Silvia Children's Hospital, Gothenburg, Sweden; 11 National Institute of Health Promotion, University of Pécs, Pécs, Hungary; 12 Institute of Statistics, Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany

Autori CNR:


Lingua: inglese

Abstract: Context: Activity of delta-9, delta-6 and delta-5 desaturases (D9D, D6D, D5D) are associated with obesity, insulin resistance and dyslipidemia. Objective: To investigate the association of estimated desaturase activities with weight status, insulin resistance, and dyslipidemia in children, cross-sectionally and longitudinally. Design: IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort study, with examinations at baseline (T0) and after two years (T1). Setting and participants: Children aged 2 to 10 years from eight European countries were recruited in kindergartens/primary schools. Children with available data on fatty acids (FA), outcome and covariate information were included in the analyses. Methods: Whole blood FA were analyzed in 2600 children at baseline. D9D (16:1n-7/16:0), D6D (20:3n-6/18:2n-6) and D5D (20:4n-6/20:3n-6) activities were estimated from product-precursor FA ratios. Body mass index (BMI), Homeostatic Model Assessment index (HOMA), and high density lipoprotein cholesterol (HDL) and triglycerides (TG) served as outcomes for weight status, insulin resistance and dyslipidemia, respectively. Linear and logistic regression and repeated measures models were used to assess the cross-sectional and longitudinal associations between desaturase activity and outcomes. Results: In the cross-sectional analysis, D9D and D6D were positively associated with BMI and TG z-scores and inversely with HDL z-scores. D5D was inversely associated with BMI and TG z-scores, i.e. a D5D increase of 1 unit is associated with a BMI z-score decrease of 0.07 and a 28% lower odds ratio for TG 75th percentile. Longitudinally, similar associations were found for T0 desaturase activities with BMI and for T0 D6D with HDLat follow-up (T1). Baseline D6D and D5D were positively associated with the change of HDL z-score from T0 to T1, and D6D with the change of HOMA z-score. Conclusion: Desaturase activities are associated with metabolic risk markers already in young children and appear to predict the metabolic risk.

Lingua abstract: inglese

Pagine da: 3760

Pagine a: 3769


The Journal of clinical endocrinology and metabolism Endocrine Society
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 0021-972X

Numero volume: 100

Numero fascicolo: 10

DOI: 10.1210/jc.2015-2693

Referee: Sì: Internazionale

Stato della pubblicazione: Published version

Parole chiave:

  • desaturase
  • weight
  • children

Strutture CNR:


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