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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in atti di convegno anno 2011

Contributo in atti di convegno

Tipo: Contributo in atti di convegno

Titolo: A computational strategy to investigate relevant similarities between virus and human proteins: Local high similarities between herpes and human proteins

Anno di pubblicazione: 2011

Formato: Elettronico

Autori: Marabotti, A., Cirielli, C.,D'Arcangelo, D.A., Giampietri, C., Facchiano, F., Facchiano, A.,Facchiano, A.M.

Affiliazioni autori: Istituto di Tecnologie Biomediche, CNR, Segrate (MI), Italy; Istituto di Scienze dell'Alimentazione, CNR, Avellino, Italy; Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy; Department of Histology and Medical Embryology, Sapienza University of Rome, Italy; Dipartimento Ematologia, Oncologia e Medicina Molecolare, Istituto Superiore di Sanit

Autori CNR:

  • ANGELO FACCHIANO

Lingua: inglese

Abstract: Investigating primary sequence and structural features of viral proteins/genes has revealed molecular mimicry and evolutionary relationship linking viruses to eukaryotes. The continuous improvement in sequencing-techniques makes available almost daily the whole genome/proteome of several microorganisms, making now possible systematic analyses of evolutionary correlations and accurate phylogeny investigations. In the present study we set up a methodology to identify significant and relevant similarities between viral and human proteomes. To this aim, the following steps were applied: i) identification of local similarity corresponding to continuous identity over at least 8-residues long fragments; ii) filtering results for statistical significance of the identified similarities, according to BLAST parameters for short sequences; iii) additional filters applied to the BLAST outputs, to select specific viruses. The present study indicates a novel accurate methodology to find relevant similarities among virus and human proteomes, useful to further investigate pathogenic mechanisms underlying infectious and non-infectious diseases.

Lingua abstract: inglese

Pagine da: 183

Pagine a: 188

ISBN: 9789898425362

Referee: Sė: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: Scopus [2-s2.0-79960194012]

Parole chiave:

  • Additional filters
  • Autoimmunity
  • Computational strategy
  • Continuous improvements
  • Evolutionary relationships
  • Human proteins
  • Local similarity
  • Molecular mimicry
  • Pathogenic mechanisms
  • Primary sequences
  • Proteomes
  • Short sequences
  • Statistical significance
  • Structural feature
  • Systematic analysis
  • Viral proteins
  • Biology
  • Evolutionary algorithms
  • Investments
  • Mathematical models
  • Viruses
  • Bioinformatics

URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-79960194012&partnerID=40&md5=96b55011fe5d37646997beb4e074eb07

Congresso nome: BIOINFORMATICS2011

Congresso data: 2011

Congresso rilevanza: Internazionale

Congresso relazione: Contributo

Altre informazioni: cited By 0; Conference of International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2011 ; Conference Date: 26 January 2011 Through 29 January 2011; Conference Code:85511

Strutture CNR:

 
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