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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2015

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Associations between early body mass index trajectories and later metabolic risk factors in European children: the IDEFICS study

Anno di pubblicazione: 2015

Formato: Elettronico

Autori: Bornhorst C.; Tilling K.; Russo P.; Kourides Y.; Michels N.; Molnar D.; Rodriguez G.; Moreno L.A.; Krogh V.; Ben-Shlomo Y.; Ahrens W.; Pigeot I.

Affiliazioni autori: Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstr. 30, Bremen, 28359, Germany; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Institute of Food Sciences, National Research Council, Avellino, Italy; Department of Chronic Diseases, National Institute for Health Development, Tallinn, Estonia; Department of Public Health, Ghent University, Ghent, Belgium; Department of Pediatrics, University of Pécs, Pecs, Hungary; GENUD (Growth, Exercise, Nutrition and Development) Research Group, Faculty of Health Sciences, University of Zaragoza, Zaragoza, Spain; IIS Aragón (Aragon Health Research Institute), Zaragoza, Spain; Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Institute of Statistics, Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany

Autori CNR:


Lingua: inglese

Abstract: Faster growth seems to be a common factor in several hypotheses relating early life exposures to subsequent health. This study aims to investigate the association between body mass index (BMI) trajectories during infancy/childhood and later metabolic risk in order to identify sensitive periods of growth affecting health. In a first step, BMI trajectories of 3301 European children that participated in the multi-centre Identification and Prevention of Dietary and Lifestyle-induced Health Effects in Children and Infants (IDEFICS) study were modelled using linear-spline mixed-effects models. The estimated random coefficients indicating initial subject-specific BMI and rates of change in BMI over time were used as exposure variables in a second step and related to a metabolic syndrome (MetS) score and its single components based on conditional regression models (mean age at outcome assessment: 8.5 years). All exposures under investigation, i.e. BMI at birth, rates of BMI change during infancy (0 to <9 months), early childhood (9 months to <6 years) and later childhood (>=6 years) as well as current BMI z-score were significantly associated with the later MetS score. Associations were strongest for the rate of BMI change in early childhood (1.78 [1.66; 1.90]; ? estimate and 99 % confidence interval) and current BMI z-score (1.16 [0.96; 1.38]) and less pronounced for BMI at birth (0.62 [0.47; 0.78]). Results slightly differed with regard to the single metabolic factors. Starting from birth rapid BMI growth, especially in the time window of 9 months to <6 years, is significantly related to later metabolic risk in children. Much of the associations of early BMI growth may further be mediated through the effects on subsequent BMI growth.

Lingua abstract: inglese

Pagine totali: 13


European journal of epidemiology Tipografia La Commerciale
Paese di pubblicazione: Italia
Lingua: inglese
ISSN: 0393-2990

DOI: 10.1007/s10654-015-0080-z

Referee: Sě: Internazionale

Stato della pubblicazione: Published version

Indicizzato da: Scopus [2-s2.0-84939839096]

Parole chiave:

  • Childhood BMI growth
  • Data reduction
  • IDEFICS study
  • Linear-spline mixed-effects model
  • Metabolic risk score

URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84939839096&partnerID=q2rCbXpz

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