|Home | English version | Mappa | Commenti | Sondaggio | Staff | Contattaci||Cerca nel sito|
|Istituto di scienza dell'alimentazione|
Contributo in rivista
Tipo: Articolo in rivista
Titolo: TAS1R3 and UCN2 Transcript Levels in Blood Cells Are Associated With Sugary and Fatty Food Consumption in Children.
Anno di pubblicazione: 2015
Formato: Elettronico Cartaceo
Autori: Priego, T; Sanchez, J; Pico, C; Ahrens, W; De Henauw, S; Kourides, Y; Lissner, L; Molnar, D; Moreno, L A; Russo, P; Siani, A; Veidebaum, T; Palou, A
Affiliazioni autori: Balearic Islands (UIB) and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Palma de Mallorca, Spain; 2. Leibniz Institute for Prevention Research and Epidemiology--BIPS, Bremen, Germany.; 3. Institute of Statistics, Faculty of Mathematics and Computer Science, Bremen University, Bremen, Germany; 4. Department of Public Health/Department of Movement and Sport Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium; 5. Research and Education of Child Health Institute, Strovolos, Cyprus; 6. Department of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden; 7. Department of Pediatrics, University of Pécs, Pécs, Hungary; 8. GENUD (Growth, Exercise, Nutrition and Development) Research group, Facultad de Ciencias de la Salud, University of Zaragoza, Zaragoza, Spain; 9. Institute of Food Sciences, Unit of Epidemiology and Population Genetics, National Research Council, Avellino, Italy; 10. National Institute for Health Development, Tervise Arengu Instituut, Tallinn, Estonia.
Abstract: Context: New types of dietary exposure biomarkers are needed to implement effective strategies for obesity prevention in children. Of special interest are biomarkers of consumption of food rich in simple sugars and fat, as their intake has been associated with obesity development. Peripheral blood cells (PBCs) represent a new promising tool for identifying novel transcript-based biomarkers. Objective: To study potential associations between the transcripts of taste-receptor-type-1-member- 3 (TAS1R3) and urocortin II (UCN2) genes in PBCs and the frequency of sugary and fatty food consumption in children. Design, setting and participants: 463 children from the IDEFICS cohort selected to include similar number of boys and girls, with normal-weight and overweight, belonging to eight European countries. Main outcome measures: Anthropometric parameters (measured at baseline and in a subset of 193 children after two years), food consumption frequency and transcript levels of TAS1R3 and UCN2 genes in PBCs. Results: Children with low frequency consumption of sugary foods displayed higher TAS1R3 expression levels with respect to those with intermediate or high frequency. In turn, children with high frequency consumption of fatty foods showed lower UCN2 expression levels with respect to those with low or intermediate frequency. Moreover, transcripts of TAS1R3 were related with BMI and fat-mass changes after a two-year follow-up period, with low expression levels of this gene being related with increased fat accumulation overtime. Conclusion: The transcripts of TAS1R3 andUCN2in PBCsmaybe considered as potential biomarkers of consumption of sugary and fatty food, respectively, to complement data of food-intake questionnaires.
Lingua abstract: inglese
Pagine da: 3556
Pagine a: 3564
The Journal of clinical endocrinology and metabolism
Numero volume: 100
Numero fascicolo: 9
Referee: Sì: Internazionale
Stato della pubblicazione: Published version
Indicizzato da: ISI Web of Science (WOS) 
|Home | Il CNR | I servizi | News | Eventi | Istituti | Focus|