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Contributo in rivista
Tipo: Articolo in rivista
Titolo: C-reactive protein reference percentiles among pre-adolescent children in Europe based on the IDEFICS study population.
Anno di pubblicazione: 2014
Autori: Schlenz, H; Intemann, T; Wolters, M; Gonzalez-Gil, E M; Nappo, A; Fraterman, A; Veidebaum, T; Molnar, D; Tornaritis, M; Sioen, I; Marild, S; Iacoviello, L; Ahrens, W
Affiliazioni autori: 1Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany. 2Growth, Exercise, Nutrition and Development (GENUD) Research Group, University of Zaragoza, Zaragoza, Spain. 3Unit of Epidemiology and Population Genetics, Institute of Food Sciences, National Research Council, Avellino, Italy. 4Medizinisches Versorgungszentrum Dr Eberhard und Partner Dortmund, Laboratoriumsmedizin, Dortmund, Germany. 5National Institute for Health Development, Tallinn, Estonia. 6National Institute of Health Promotion, University of Pécs, Pécs, Hungary. 7Research and Education Institute of Child Health, Strovolos, Cyprus. 8Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. 9Department of Paediatrics, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. 10Laboratory of Molecular and Nutritional Epidemiology, Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo, NEUROMED, Italy. 111] Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany  Institute of Statistics, Faculty of Mathematics and Computer Science, Bremen University, Bremen, Germany.
Abstract: OBJECTIVES: C-reactive protein (CRP) is involved in a wide range of diseases. It is a powerful marker for inflammatory processes used for diagnostic and monitoring purposes. We aimed to establish reference values as data on the distribution of serum CRP levels in young European children are scarce. SUBJECTS: Reference values of high-sensitivity CRP concentrations were calculated for 9855 children aged 2.0-10.9 years, stratified by age and sex. The children were recruited during the population-based European IDEFICS study (Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and infantS) with 18 745 participants recruited from 2007 to 2010. RESULTS: In 44.1% of the children, CRP values were below or equal the detection limit of 0.2 mg/l. Median CRP concentrations showed a slight negative age trend in boys and girls, whereas serum CRP values were slightly higher in girls than in boys across all age groups. CONCLUSIONS: Our population-based reference values of CRP may guide paediatric practice as elevated values may require further investigation or treatment. Therefore, the presented reference values represent a basis for clinical evaluation and for future research on risk assessment of diseases associated with increased CRP levels among children.
Lingua abstract: inglese
Pagine da: S26
Pagine a: 31
Pagine totali: 6
International journal of obesity. Supplement
Numero volume: 38 Suppl 2
Referee: Sě: Internazionale
Indicizzato da: ISI Web of Science (WOS) 
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