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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2014

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Members of the novel UBASH3/STS/TULA family of cellular regulators suppress T-cell-driven inflammatory responses in vivo

Anno di pubblicazione: 2014

Formato: Cartaceo

Autori: Newman, Tiffanny N.; Liverani, Elisabetta; Ivanova, Elitza; Russo, Gian L.; Carpino, Nick; Ganea, Doina; Safadi, Fayez; Kunapuli, Satya P.; Tsygankov, Alexander Y.

Affiliazioni autori: Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania Commonwealth System of Higher Education (PCSHE); State University of New York (SUNY) Stony Brook; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania Commonwealth System of Higher Education (PCSHE); Northeast Ohio Med Univ; Pennsylvania Commonwealth System of Higher Education (PCSHE)

Autori CNR:


Lingua: inglese

Abstract: The UBASH3/STS/TULA family consists of two members sharing substantial homology and a similar multi-domain architecture, which includes a C-terminal histidine phosphatase domain capable of dephosphorylating phosphotyrosine-containing substrates. TULA-family proteins act as downregulators of receptor-induced activation in several cell types, including T cells and platelets. Deletion of both family members in mice has been shown to result in hyperresponsiveness of T cells to T-cell receptor (TCR)/CD3 complex engagement, but little is known about the biological consequences of double knockout (dKO) and especially of either single KO (sKO). We elucidated the biological consequences of the lack of TULA-family proteins in dKO and TULA and TULA-2 sKO animals. In order to do so, we examined immune responses in Trinitrobenzene sulfonic acid (TNBS)-induced colitis, a mouse model of human inflammatory bowel disease, which is characterized by the involvement of multiple cell types, of which T cells have a crucial role, in the development of a pathological inflammatory condition. Our data indicate that TNBS treatment upregulates T-cell responses in all KO mice studied to a significantly higher degree than in wild-type mice. Although the lack of either TULA-family member exacerbates inflammation and T-cell responses in a specific fashion, the lack of both TULA and TULA-2 in dKO exerts a higher effect than the lack of a single family member in TULA and TULA-2 sKO. Analysis of T-cell responses and TCR-mediated signaling argues that the proteins investigated affect T-cell signaling by regulating phosphorylation of Zap-70, a key protein tyrosine kinase.

Lingua abstract: inglese

Pagine da: 837

Pagine a: 850

Pagine totali: 14


Immunology and cell biology University of Adelaide,
Paese di pubblicazione: Australia
Lingua: inglese
ISSN: 0818-9641

Numero volume: 92

Numero fascicolo: 10

DOI: 10.1038/icb.2014.60

Referee: Sė: Internazionale

Indicizzato da: ISI Web of Science (WOS) [000345496900005]

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