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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2013

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Protective effect of gamma-irradiation against hypochlorous acidinduced haemolysis in human erythrocytes

Anno di pubblicazione: 2013

Autori: I. Tedesco; C. Spagnuolo; M. Russo; R. Iannitti; A. Nappo; G.L. Russo. Protective effect of ?-irradiation against hypochlorous acidinduced haemolysis in human erythrocytes. Dose-Response 11:401-12 (2013)

Affiliazioni autori: Istituto Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche

Autori CNR:

  • ROBERTA IANNITTI
  • ANNUNZIATA NAPPO
  • GIAN LUIGI RUSSO
  • MARIA RUSSO
  • CARMELA SPAGNUOLO
  • IDOLO TEDESCO

Lingua: inglese

Abstract: Radiations may trigger protective response within a threshold of doses applied. Exposures above an upper threshold are generally detrimental, while exposures below a lower threshold may or may not increase risks for health. We recently reported that a cellular protective response occurs in interventional cardiologists to counteract the oxidative damage caused by radiation. Here, we demonstrated in an in vitro model represented by whole blood of healthy donors ?-irradiated with 220-440 mGy, that haemolysis of erythrocytes induced by hypochlorous acid was reduced by 40%. The protection triggered by ?- radiations made erythrocytes more resistant to oxidative insult caused by hypochlorous acid which was induced 3 h after irradiation and involved biochemical changes in the synthesis and turnover of glutathione. Overall, the biochemical remodelling induced by exposure to ?-radiations might contribute to generate new guidelines in professionally exposed workers.

Lingua abstract: inglese

Pagine da: 401

Pagine a: 412

Pagine totali: 12

Rivista:

Dose-response International Hormesis Society,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1559-3258

Numero volume: 11

DOI: 10.2203/dose-response.12-025

Referee: Sė: Internazionale

Parole chiave:

  • ionizing radiation; reactive oxygen species; GSH; hypochlorous acid; human erythrocytes

URL: http://www.dose-response.com/

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