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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2014

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Cytotoxic Properties of Lyophilized Beers in a Malignant Cell Line

Anno di pubblicazione: 2014

Autori: C. Spagnuolo, I. Tedesco, M.G. Volpe, S. Bilotto, M. Russo, G.L. Russo.

Affiliazioni autori: Istituto Scienze Alimentazione, CNR

Autori CNR:

  • STEFANIA BILOTTO
  • GIAN LUIGI RUSSO
  • MARIA RUSSO
  • CARMELA SPAGNUOLO
  • IDOLO TEDESCO
  • MARIA GRAZIA VOLPE

Lingua: inglese

Abstract: Moderate beer consumption can be considered as part of a healthy diet since it may protect against heart disease, cancer and osteoporosis. The protective effects of beer reside in its polyphenol content whose chemical composition appears extremely complex. In the present study, five commercial beers with different polyphenol content (ranging between 690 - 2400 ?M equivalents of quercetin) were employed to investigate their cytotoxic effect in vitro on HL-60 cells derived from a human promyelocytic leukemia cell line. A significant reduction in cell viability was measured after 48 hours treatment. Lyophilized beers with higher polyphenol content showed the highest cytotoxicity compared to those with lower concentrations. However, when the assay was performed applying equal amounts of total polyphenols from different lyophilized beers, the sample possessing lowest amount of polyphenols (690 ?M equivalents of quercetin) resulted the most effective in reducing cell viability. These data suggest that the biological activities of polyphenols present in beer are not simply dependent upon their total concentration, but qualitative profile and relative concentrations are even more important in determining their antiproliferative effects on cancer cells.

Lingua abstract: inglese

Pagine da: 45

Pagine a: 51

Rivista:

Food and nutrition sciences Scientific Research Pub.
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 2157-944X

Numero volume: 5

DOI: 10.4236/fns.2014.51006

Referee: Sė: Internazionale

Parole chiave:

  • Beers
  • Cytotoxicity
  • Polyphenol
  • Flavonoids
  • HL-60

URL: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=41715#.VOry13xfbTo

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