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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2014

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Percentiles of fasting serum insulin, glucose, HbA1c and HOMA-IR in pre-pubertal normal weight European children from the IDEFICS cohort.

Anno di pubblicazione: 2014

Autori: Peplies, J; Jimenez-Pavon, D; Savva, S C; Buck, C; Gunther, K; Fraterman, A; Russo, P; Iacoviello, L; Veidebaum, T; Tornaritis, M; De Henauw, S; Marild, S; Molnar, D; Moreno, L A; Ahrens, W

Affiliazioni autori: 1Leibniz Institute for Prevention Research and Epidemiology--BIPS, Bremen, Germany; 2GENUD (Growth, Exercise, Nutrition and Development) Research Group, School of Health Sciences, University of Zaragoza, Zaragoza, Spain; 3Research & Education Institute of Child Health, Strovolos, Cyprus; 4Medizinisches Versorgungszentrum (MVZ), Dr Eberhard und Partner Dortmund, Dortmund, Germany; 5Epidemiology and Population Genetics, Institute of Food Science, CNR, Avellino, Italy; 6Centre for High Technology Research and Education in Biomedical Sciences, Universita Cattolica del Sacro Cuore, Campobasso, Italy; 7National Institute for Health Development (NIHD), Tallinn, Estonia; 8Department of Public Health, Ghent University, Ghent, Belgium; 9Department of Paedriatrics, The Queen Silvia Children's Hospital, Gothenburg, Sweden; 10Chronic Diseases Department, National Institute of Health Promotion, University of Pécs, Pécs, Hungary and 11Institute of Statistics, Faculty of Mathematics and Computer Science, University Bremen, Bremen, Germany.

Autori CNR:


Lingua: inglese

Abstract: OBJECTIVES: The aim of this study is to present age- and sex-specific reference values of insulin, glucose, glycosylated haemoglobin (HbA1c) and the homeostasis model assessment to quantify insulin resistance (HOMA-IR) for pre-pubertal children. METHODS: The reference population consists of 7074 normal weight 3- to 10.9-year-old pre-pubertal children from eight European countries who participated in at least one wave of the IDEFICS ('identification and prevention of dietary- and lifestyle-induced health effects in children and infants') surveys (2007-2010) and for whom standardised laboratory measurements were obtained. Percentile curves of insulin (measured by an electrochemiluminescence immunoassay), glucose, HbA1c and HOMA-IR were calculated as a function of age stratified by sex using the general additive model for location scale and shape (GAMLSS) method. RESULTS: Levels of insulin, fasting glucose and HOMA-IR continuously show an increasing trend with age, whereas HbA1c shows an upward trend only beyond the age of 8 years. Insulin and HOMA-IR values are higher in girls of all age groups, whereas glucose values are slightly higher in boys. Median serum levels of insulin range from 17.4 and 13.2 pmol l- 1 in 3- < 3.5-year-old girls and boys, respectively, to 53.5 and 43.0 pmol l - 1 in 10.5- < 11-year-old girls and boys. Median values of glucose are 4.3 and 4.5 mmol l - 1 in the youngest age group and 49.3 and 50.6 mmol l - 1 in the oldest girls and boys. For HOMA-IR, median values range from 0.5 and 0.4 in 3- < 3.5-year-old girls and boys to 1.7 and 1.4 in 10.5- < 11-year-old girls and boys, respectively. CONCLUSIONS: Our study provides the first standardised reference values for an international European children's population and provides the, up to now, largest data set of healthy pre-pubertal children to model reference percentiles for markers of insulin resistance. Our cohort shows higher values of Hb1Ac as compared with a single Swedish study while our percentiles for the other glucose metabolic markers are in good accordance with previous studies.

Lingua abstract: inglese

Pagine da: S39

Pagine a: 47

Pagine totali: 9


International journal of obesity Macmillan, Nature Publishing
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 0307-0565

Numero volume: 38 Suppl 2

DOI: 10.1038/ijo.2014.134

Referee: Sě: Internazionale

Indicizzato da: ISI Web of Science (WOS) [25376219]

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