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Contributo in rivista
Tipo: Articolo in rivista
Titolo: Blood lipids among young children in Europe: results from the European IDEFICS study.
Anno di pubblicazione: 2014
Autori: De Henauw, S; Michels, N; Vyncke, K; Hebestreit, A; Russo, P; Intemann, T; Peplies, J; Fraterman, A; Eiben, G; de Lorgeril, M; Tornaritis, M; Molnar, D; Veidebaum, T; Ahrens, W; Moreno, L A
Affiliazioni autori: 1Department of Public Health, Faculty of Medicine and Health Sciences, University Hospital, Ghent University, Ghent, Belgium; 2Department of Health Sciences, Vesalius College, University College Ghent, Ghent, Belgium; 3Leibniz Institute for Prevention Research and Epidemiology--BIPS, Bremen, Germany; 4Epidemiology and Population Genetics, Institute of Food Sciences, CNR, Avellino, Italy; 5MVZ Dortmund Dr Eberhard und Partner, Dortmund, Germany; 6Department of Primary Health Care, University of Gothenburg, Gothenburg, Sweden; 7TIMC-IMAG, CNRS UMR 5525, Coeur et nutrition, Faculté de Médecine de Grenoble, Grenoble, France; 8Research and Education Institute of Child Health, Strovolos, Cyprus; 9National Institute of Health Promotion, University of Pécs, Gyermekklinika, Pécs, Hungary; 10Department of Chronic Diseases, National Institute for Health Development, Tallinn, Estonia; 11Institute of Statistics, Faculty of Mathematics and Computer Science, University Bremen, Bremen, Germany and 12GENUD (Growth, Exercise, Nutrition and Development) research group, School of Health Sciences, University of Zaragoza, Zaragoza, Spain.
Abstract: BACKGROUND: Measurement of cholesterol and triglyceride (TG) fractions in blood has become standard practice in the early detection of atherosclerotic disease pathways. Considerable attention is given nowadays to the presence of these risk factors in children and to start preventive campaigns early in life. In this context, it is imperative to have valid comparative frameworks for interpretation of lipid levels. The aim of this study is to present sex- and age-specific reference values on blood lipid levels in European children aged 2.0-10.9 years. METHODS: Fasting blood was obtained via either venipuncture or capillary sampling. In 13,579 European non-obese children (50.3% boys), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), TG and TC/HDL-C ratio levels were measured with a point-of-care analyser (Cholestech). Sex- and age-specific reference values were computed with the GAMLSS method with the statistical software R. RESULTS: Reference curves and 1st, 3rd, 10th, 25th, 50th, 75th, 90th, 97th and 99th percentile values are presented. HDL-C showed a positive trend with age, from 2 years onwards, but was relatively stable above the age of 7. For LDL-C and TC, linear but small age-related trends were seen. The TC/HDL-C values showed a gradual negative trend from the age of 2 up to 6 and were relatively stable afterwards. For TG, no age trend was found (P=0.285). Boys had higher mean HDL-C values than girls (1.414 vs 1.368mmoll(-1)), and lower TC, LDL-C, TC/HDL-C and TG values (3.981 vs 4.087mmoll(-1); 2.297 vs 2.435mmoll(-1); 2.84 vs 3.01mmoll(-1); and 0.509 vs 0.542mmoll(-1), respectively). CONCLUSIONS: These new and recent references could serve as a European orientation of blood lipid values in children in the context of standard medical practice and for the purpose of public health screening.
Lingua abstract: inglese
Pagine da: S67
Pagine a: 75
Pagine totali: 9
International journal of obesity
Macmillan, Nature Publishing
Numero volume: 38 Suppl 2
Referee: Sì: Internazionale
Indicizzato da: ISI Web of Science (WOS) 
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