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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2013

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Understanding the Links among neuromedin U Gene, beta2-adrenoceptor Gene and Bone Health: An Observational Study in European Children

Anno di pubblicazione: 2013

Autori: Gianfagna F.; Cugino D.; Ahrens W.; Bailey M.E.S.; Bammann K.; Herrmann D.; Koni A.C.; Kourides Y.; Marild S.; Molnar D.; Moreno L.A.; Pitsiladis Y.P.; Russo P.; Siani A.; Sieri S.; Sioen I.; Veidebaum T.; Iacoviello L.

Affiliazioni autori: Research Laboratories, Fondazione di Ricerca e Cura Giovanni Paolo II, Universitŕ Cattolica del Sacro Cuore, Campobasso, Italy; Casa di Cura Montevergine, Mercogliano (AV), Italy; Department of Epidemiological Methods and Etiologic Research, Leibniz-Institute for Prevention Research and Epidemiology - BIPS GmbH, Bremen, Germany; Department of Mathematics and Computer Sciences, University of Bremen, Bremen, Germany; School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; Institute for Public Health and Nursing Research, University of Bremen, Bremen, Germany; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; Research and Education Institute of Child Health, Strovolos, Cyprus; Department of Pediatrics, Institute of Clinical Sciences, The Queen Silvia Children's Hospital, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden; Department of Pediatrics, University of Pécs, Pécs, Hungary; GENUD (Growth, Exercise, NUtrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain; Epidemiology and Population Genetics, Institute of Food Sciences, CNR, Avellino, Italy; Department of Preventive and Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Department of Public Health, Ghent University, Ghent, Belgium; FWO, Research Foundation Flanders, Brussels, Belgium; Center of Health and Behavioral Science, National Institute for Health Development, Tallinn, Estonia; Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli (IS), Italy

Autori CNR:


Lingua: inglese

Abstract: Neuromedin U, encoded by the NMU gene, is a hypothalamic neuropeptide that regulates both energy metabolism and bone mass. The beta-2 adrenergic receptor, encoded by the ADRB2 gene, mediates several effects of catecholamine hormones and neurotransmitters in bone. We investigated whether NMU single nucleotide polymorphisms (SNPs) and haplotypes, as well as functional ADRB2 SNPs, are associated with bone stiffness in children from the IDEFICS cohort, also evaluating whether NMU and ADRB2 interact to affect this trait. A sample of 2,274 subjects (52.5% boys, age 6.2±1.8 years) from eight European countries, having data on calcaneus bone stiffness index (SI, mean of both feet) and genotyping (NMU gene: rs6827359, rs12500837, rs9999653; ADRB2 gene: rs1042713, rs1042714), was studied. After false discovery rate adjustment, SI was significantly associated with all NMU SNPs. rs6827359 CC homozygotes showed the strongest association (recessive model, ? = -1.8, p = 0.006). Among the five retrieved haplotypes with frequencies higher than 1% (range 2.0-43.9%), the CCT haplotype (frequency = 39.7%) was associated with lower SI values (dominant model, ? = -1.0, p = 0.04) as compared to the most prevalent haplotype. A non-significant decrease in SI was observed in in ADRB2 rs1042713 GG homozygotes, while subjects carrying SI-lowering genotypes at both SNPs (frequency = 8.4%) showed much lower SI than non-carriers (? = -3.9, p<0.0001; p for interaction = 0.025). The association was more evident in preschool girls, in whom SI showed a curvilinear trend across ages. In subgroup analyses, rs9999653 CC NMU or both GG ADRB2 genotypes were associated with either lower serum calcium or ?-CrossLaps levels (p = 0.01). This study in European children shows, for the first time in humans, a role for NMU gene through interaction with ADRB2 gene in bone strength regulation, more evident in preschool girls. © 2013 Gianfagna et al.

Lingua abstract: inglese

Pagine da: e70632


PloS one Public Library of Science
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1932-6203

Numero volume: 8

Numero fascicolo: 8

DOI: 10.1371/journal.pone.0070632

Referee: Sě: Internazionale

Indicizzato da: Scopus [2-s2.0-84880992863]

URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84880992863&partnerID=q2rCbXpz

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