Home |  English version |  Mappa |  Commenti |  Sondaggio |  Staff |  Contattaci Cerca nel sito  
Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2014

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Influence of breastfeeding on blood-cell transcript-based biomarkers of health in children

Anno di pubblicazione: 2014

Autori: Priego, T.; Sanchez, J.; Pico, C.; Ahrens, W.; Bammann, K.; De Henauw, S.; Fraterman, A.; Iacoviello, L.; Lissner, L.; Molnar, D.; Moreno, L. A.; Siani, A.; Tornaritis, M.; Veidebaum, T.; Palou, A.

Affiliazioni autori: Universitat de les Illes Balears; CIBER Fisiopatol Obesidad & Nutr CIBERobn; University of Bremen; BIPS Inst Epidemiol & Prevent Res GmbH; University of Bremen; Ghent University; MVZ Eberhard & Partner Lab Med; IRCCS Ist Neurol Mediterraneo Neuromed; University of Gothenburg; University of Pecs; University of Zaragoza; Consiglio Nazionale delle Ricerche (CNR); Res & Educ Child Hlth Inst; National Institute for Health Development - Estonia

Autori CNR:

  • ALFONSO SIANI

Lingua: inglese

Abstract: Background: Blood-cell transcripts have showed to be good biomarkers of metabolic alterations and their use in early detection and prevention of future disorders is promising. Objective: This study aimed to examine the relation between previously proposed transcriptional biomarkers of metabolic health (SLC27A2, CPT1A, FASN, PPAR?, INSR, LEPR) in peripheral blood cells and the type of infant feeding in a subset of children from the IDEFICS (Identification and Prevention of Dietaryand Lifestyle-Induced Health Effects in Children and Infants) cohort. Subjects: A total of 237 children aged 2-9 years from eight European countries were studied. Results: Breastfed children showed higher expression levels of SLC27A2, FASN, PPAR? and INSR, and lower risk of being overweight and of having high plasma triglyceride levels vs. formula-fed children. Besides, overweight formula-fed children presented higher HOMA-index than overweight breastfed children (1.90 vs. 1.62); however, this negative effect was absent in formula-fed children with high expression of SLC27A2. Moreover, formula-fed children with low expression of SLC27A2, FASN, PPAR? and INSR presented higher triglyceride levels than subjects with high expression of these genes (77.7 mg dL-1 vs. 44.8 mg dL-1). This difference was absent in breastfed children. Conclusions: Protective effects of breastfeeding are reflected in higher expression levels of SLC27A2, FASN, PPAR? and INSR in blood cells. These biomarkers may also serve to discriminate the formula-fed children that are at higher risk of metabolic alterations.

Lingua abstract: inglese

Pagine da: 463

Pagine a: 470

Pagine totali: 8

Rivista:

pediatric obesity wiley
Paese di pubblicazione:
Lingua: inglese

Numero volume: 9

Numero fascicolo: 6

DOI: 10.1111/j.2047-6310.2013.00204.x

Referee: Ś: Internazionale

Indicizzato da: ISI Web of Science (WOS) [000345365100015]

Parole chiave:

  • Formula-feeding
  • IDEFICS project
  • lactation
  • metabolic alteration

Strutture CNR:

Moduli:

 
Torna indietro Richiedi modifiche Invia per email Stampa
Home Il CNR  |  I servizi News |   Eventi | Istituti |  Focus