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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2014

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Rapid peptidomic profiling of peritoneal fluid by MALDI-TOF mass spectrometry for the identification of biomarkers of endometriosis

Anno di pubblicazione: 2014

Formato: Elettronico Cartaceo

Autori: Siciliano R.A.; Mazzeo M.F.; Spada V.; Facchiano A.; D'acierno A.; Stocchero M.; De Franciscis P.; Colacurci N.; Sannolo N.; Miraglia N.

Affiliazioni autori: Institute of Food Sciences, National Research Council (CNR), Avellino, Italy; S-IN Soluzioni Informatiche, Vicenza, Italy; Department of Obstetrics and Gynaecology, Second University of Naples, Largo Madonna delle Grazie 1, Naples, 80138, Italy; Department of Experimental Medicine, Section of Hygiene, Occupational and Forensic Medicine, Second University of Naples, Naples, Italy

Autori CNR:

  • ANTONIO D'ACIERNO
  • ANGELO FACCHIANO
  • MARIA FIORELLA MAZZEO
  • ROSA ANNA SICILIANO

Lingua: inglese

Abstract: Peptidomic profiling of peritoneal fluid by Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF-MS) may represent a promising, suitable, rapid method for early diagnosis and staging of endometriosis. In a case-control study, peritoneal fluid was collected from 23 patients affected by endometriosis (eight minimal/mild endometriosis and 15 moderate/severe endometriosis) and six "endometriosis free" women undergoing laparoscopy. MALDI-TOF mass spectra of the peptide fraction extracted from peritoneal fluid samples lead to identify biomarkers potentially suitable for discriminating between peritoneal fluid samples from women affected by minimal/mild endometriosis and those from women affected by moderate/severe endometriosis. Peptidomic analysis of peritoneal fluid samples may define putative peptide biomarkers suitable for staging endometriosis and improve our understanding of the pathogenesis of endometriosis.

Lingua abstract: inglese

Pagine da: 872

Pagine a: 876

Rivista:

Gynecological endocrinology CRC Press
Paese di pubblicazione: Regno Unito
Lingua: inglese
ISSN: 1473-0766

Numero volume: 30

Numero fascicolo: 12

DOI: 10.3109/09513590.2014.943718

Referee: Sė: Internazionale

Indicizzato da: Scopus [2-s2.0-84910681947]

Parole chiave:

  • Biomarkers
  • Endometriosis
  • Laparoscopy
  • MALDI-TOF-MS
  • Peptidomics

URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84910681947&partnerID=q2rCbXpz

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