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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2013

Contributo in rivista

Tipo: Articolo in rivista

Titolo: T300A Variant of Autophagy ATG16L1 Gene is Associated with Decreased Antigen Sampling and Processing by Dendritic Cells in Pediatric Crohn's Disease

Anno di pubblicazione: 2013

Autori: Strisciuglio, Caterina; Miele, Erasmo; Wildenberg, Manon E.; Giugliano, Francesca P.; Andreozzi, Marialuisa; Vitale, Alessandra; Capasso, Francesca; Camarca, Alessandra; Barone, Maria V.; Staiano, Annamaria; Troncone, Riccardo; Gianfrani, Carmela

Affiliazioni autori: University of Naples Federico II; University of Naples Federico II; University of Amsterdam; University of Amsterdam; University of Amsterdam; Consiglio Nazionale delle Ricerche (CNR)

Autori CNR:

  • ALESSANDRA CAMARCA
  • CARMELA GIANFRANI

Abstract: Background: The single-nucleotide polymorphism T300A of ATG16L1, a Crohn's disease (CD)-associated gene, is responsible for decreased autophagy. This study aimed to investigate the effects of this single-nucleotide polymorphism on the uptake and processing of antigens by dendritic cells (DCs) and the interaction between DC and intestinal epithelium in pediatric patients with CD.

Altro abstract: Methods: Pediatric patients who homozygously carry either the protective (wild type, n = 7) or risk allele (risk, n = 13) of ATG16L1, as well as heterozygous patients (het, n = 13) were enrolled. The monocyte-derived DC were analyzed for phenotype, antigen sampling, and processing by flow cytometry, whereas the capability of DC to form transepithelial protrusions was determined by confocal microscopy.

Pagine da: 2339

Pagine a: 2348

Pagine totali: 10

Rivista:

Inflammatory bowel diseases Raven Press,
Paese di pubblicazione: Stati Uniti d'America
Lingua: inglese
ISSN: 1078-0998

Numero volume: 19

Numero fascicolo: 11

DOI: 10.1097/MIB.0b013e3182a6a11c

Indicizzato da: ISI Web of Science (WOS) [000329354500009]

Parole chiave:

  • autophagy
  • Crohn's disease
  • immunity

Strutture CNR:

 
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