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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2015

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Spray-by-spray in situ cross-linking alginate hydrogels delivering a tea tree oil microemulsion

Anno di pubblicazione: 2015

Formato: Elettronico

Autori: Catanzano, Ovidio; Straccia, Maria Cristina; Miro, Agnese G F; Ungaro, Francesca; Romano, Ida; Mazzarella, Giuseppe; Santagata, Gabriella; Quaglia, Fabiana; Laurienzo, Paola; Malinconico, Mario

Affiliazioni autori: Universita degli Studi di Napoli Federico II; Consiglio Nazionale delle Ricerche

Autori CNR:

  • PAOLA LAURIENZO
  • MARIO MALINCONICO
  • GIUSEPPE MAZZARELLA
  • IDA ROMANO
  • GABRIELLA SANTAGATA

Lingua: inglese

Abstract: In this paper we propose an in situ forming ionically cross-linked alginate (Alg) hydrogel delivering a Tea Tree Oil microemulsion (MeTTO) and potentially useful as an advanced dressing for infected wounds. Alg hydrogels were prepared by a spray-by-spray deposition method with the aim to minimize the discomforts during application. From pseudoternary phase diagrams, it was found that proper combination of TTO, water, polysorbate 80 and ethanol gave stable spherical MeTTO with good antimicrobial activity. On this basis, MeTTO at 20% TTO was selected for further inclusion in an Alg hydrogel prepared by alternating sprays of Alg/MeTTO and calcium chloride solutions. Homogeneous dispersion of MeTTO inside cross-linked Alg was assessed by different macroscopic and microscopic methods demonstrating the superior propensity of MeTTO to be integrated in the water-based hydrogel as compared to TTO. Antimicrobial effect of Alg/MeTTO hydrogels on Escherichia Coli strains was remarkable, highlighting the potential of the system as bioactive wound dressing.

Lingua abstract: inglese

Pagine da: 20

Pagine a: 28

Rivista:

European journal of pharmaceutical sciences Elsevier Science Ireland
Paese di pubblicazione: Paesi Bassi
Lingua: inglese
ISSN: 0928-0987

Numero volume: 66

DOI: 10.1016/j.ejps.2014.09.018

Stato della pubblicazione: Published version

Indicizzato da: Scopus [2-s2.0-84908181087]

Parole chiave:

  • Advanced dressing
  • Alginate
  • Microemulsions
  • Spray-by-spray
  • Tea tree oil

URL: http://www.scopus.com/record/display.url?eid=2-s2.0-84908181087&origin=inward

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