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Istituto di scienza dell'alimentazione

Torna all'elenco Contributi in rivista anno 2014

Contributo in rivista

Tipo: Articolo in rivista

Titolo: Immunomodulatory activity of a gut microbial metabolite of dietary linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, associated with improved antioxidant/detoxifying defences

Anno di pubblicazione: 2014

Formato: Cartaceo

Autori: Bergamo P., Luongo D., Miyamoto J., Cocca E., Kishino S., Ogawa J., Tanabe S., Rossi M. (

Affiliazioni autori: CNR- IBBR- Napoli

Autori CNR:

  • PAOLO BERGAMO
  • ENNIO COCCA
  • DIOMIRA LUONGO
  • MAURO ROSSI

Lingua: inglese

Abstract: Various hydroxy-, oxo-, and conjugated fatty acids are generated by gut microbes throughout the metabolism of dietary PUFAs. Specifically, 10-Hydroxy-cis-12-(HYA), 10-oxo-cis12-(KetoA) and 10-oxo-cis9,trans11-octadecenoic acid (KetoC) are intermediates free fatty acids (iFFA) produced during the isomerization of dietary linoleic acid to cis9,trans11 (c9,t11) isomer of conjugated linoleic acid (CLA). Herein, immunomodulatory and antioxidant activity of selected iFFA was studied in resting (iDCs), LPS-matured DCs (mDCs) and inmurine enterocyte cells (MODE-K). Phenotypic maturation of iDCs was not influenced by iFFA, but the release of pro-inflammatory molecules from mDCs was reduced following HYA pre-treatment. HYA ability to improve antioxidant/detoxifying defenses associated with decreased expression of maturation markers in mDCs and in MODE-K cells. The pro-oxidant activity, via NADPH oxidase activation, was responsible for the pro-inflammatory effect of 10-hydroxyoctadecanoic acid. Presented data suggest that the immunomodulatory ability of HYA is determined, at least in part, by its ability to improve antioxidant/detoxifying defenses.

Lingua abstract: inglese

Pagine da: 192

Pagine a: 202.

Rivista:

Journal of Functional Foods Elsevier
Paese di pubblicazione:
Lingua: inglese
ISSN: 1756-4646

Numero volume: 11

DOI: 10.1016/j.jff.2014.10.007

Referee: Sì: Internazionale

Stato della pubblicazione: Published version

Parole chiave:

  • Fatty acids Gut microbes Immunomodulation Antioxidant Conjugated linoleic acid Dendritic cells

Strutture CNR:

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